878110C

Avanti

C16-02:0 PC

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, chloroform

Empirical Formula (Hill Notation):
C26H54NO7P
CAS号:
分子量:
523.68
价格与库存信息目前不能提供

packaging

pkg of 1 × 1 mL (878110C-5mg)
pkg of 1 × 2.5 mL (878110C-25mg)

mfr. no.

Avanti Polar Lipids, 878110C

concentration

10 mg/mL (878110C-25mg)
5 mg/mL (878110C-5mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O

InChI

1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

InChI key

HVAUUPRFYPCOCA-AREMUKBSSA-N

General description

C16-02:0 PC, also known as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is present in the body and it contains ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

Application

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet-activating factor (PAF) is used as a substrate for the determination of platelet-activating factor-acetylhydrolase (PAF-AH) activity in plasma or serum.

Biochem/physiol Actions

Platelet-activating factor (PAF) is a pro-inflammatory agent that exhibits variety of biological and pharmacological effects. It plays a major role in initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It yields LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) on hydrolysis by platelet-activating factor-acetylhydrolase.

Packaging

5 mL Clear Glass Sealed Ampule (878110C-25mg)
5 mL Clear Glass Sealed Ampule (878110C-5mg)

RIDADR

UN 1888 6.1 / PGIII

Diana M Stafforini et al.
Free radical biology & medicine, 59, 100-107 (2012-06-05)
This article presents a radiometric assay to determine the enzymatic activity of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 and phospholipase A2 group 7A. The method is based on the release of radioactively labeled acetate from...
Saki Yamaura et al.
Clinica chimica acta; international journal of clinical chemistry, 481, 184-188 (2018-03-20)
Measurement of lipoprotein-associated phospholipase A2 (Lp-PLA2) can be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of cardiovascular events. This can be performed by quantification of the protein concentration using an ELISA platform...
Sunil A Nankar et al.
Biochimie, 95(6), 1196-1207 (2013-02-05)
Apolipoprotein-derived peptides are promising candidates for the treatment of various inflammatory conditions and the main mechanism proposed for the protective action of these peptides includes binding to pro-inflammatory lipid mediators with high affinity and facilitating their sequestration/metabolism/clearance in the body....

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