880622C

Avanti

16:0-02:0 PC

1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine, chloroform

Empirical Formula (Hill Notation):
C26H52NO8P
CAS号:
分子量:
537.67
NACRES:
NA.25
价格与库存信息目前不能提供

packaging

pkg of 1 × 1 mL (880622C-5mg)
pkg of 1 × 2.5 mL (880622C-25mg)

mfr. no.

Avanti Polar Lipids, 880622C

concentration

10 mg/mL (880622C-25mg)
5 mg/mL (880622C-5mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

O-P(OCCN+(C)(C)C)(OCC@(H)(OC(C)=O)COC(CCCCCCCCCCCCCCC)=O)=O

General description

Phosphocholine (PC) is an intermediate of phosphatidylcholine synthesis catalyzed by choline kinase. It is a phosphomonoester and contributes to the membrane phospholipids. 16:0-02:0 PC is an oxidized phospholipid and an analog of platelet activating factor (PAF).

Application

16:0-02:0 PC might be used in liposomes to study the hydrolyzing action of lysosomal phospholipase A2 (LPLA2) on truncated oxidized phosphatidylcholine in vitro.

Biochem/physiol Actions

16:0-02:0 PC acts as a receptor (PAF-R) agonist. Increase in the level of phosphocholine (PC) is observed in Alzheimer′s disease.

Packaging

5 mL Clear Glass Sealed Ampule (880622C-5mg)
5 mL Clear Glass Sealed Ampule (880622C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Alejandro Torrecillas et al.
International journal of pharmaceutics, 318(1-2), 28-40 (2006-04-21)
The effect of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH(3), edelfosine), and six other analog asymmetric phosholipids on the physical properties of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes was studied using differential scanning calorimetry (DSC), (31)P-nuclear magnetic resonance ((31)P NMR) and X-ray diffraction. DSC data revealed that...
Akira Abe et al.
Journal of lipid research, 58(2), 339-349 (2016-12-21)
Truncated oxidized glycerophospholipids (ox-PLs) are bioactive lipids resulting from oxidative stress. The catabolic pathways for truncated ox-PLs are not fully understood. Lysosomal phospholipase A2 (LPLA2) with phospholipase A and transacylase activities is a key enzyme in phospholipid homeostasis. The present...
J W Geddes et al.
Neurobiology of aging, 18(3), 305-308 (1997-05-01)
At early stages of Alzheimer's disease, phosphomonoesters (PMEs) including phosphocholine (P-choline) are present at elevated levels. PMEs also are elevated in the developing brain during the period of neurite extension. To determine if the elevation of PMEs in AD could...
Valery Bochkov et al.
Free radical biology & medicine, 111, 6-24 (2016-12-29)
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests...
Current Research in Alzheimer Therapy, 95-95 (1988)

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