890700C

Avanti

12:0 EPC (Cl Salt)

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt), chloroform

Empirical Formula (Hill Notation):
C34H69NO8PCl
CAS号:
分子量:
686.34
NACRES:
NA.25
价格与库存信息目前不能提供

packaging

pkg of 1 × 1 mL (890700C-10mg)

mfr. no.

Avanti Polar Lipids, 890700C

concentration

10 mg/mL (890700C-10mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCCN+(C)(C)C)(OCC@(H)(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.Cl-

General description

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Application

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable:
  • for use in lipoplex
  • to study its effect on transfection of human umbilical artery endothelial cells (HUAEC)
  • in liposome preparation
  • in lipid mixtures to study its cubic phases of formation, stability and phase transitions

Biochem/physiol Actions

Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity.

Packaging

5 mL Clear Glass Sealed Ampule (890700C-10mg)

RIDADR

UN 1888 6.1 / PGIII

Analysis of lipoplex structure and lipid phase changes
Liposomes, 399-423 (2010)
L Wang et al.
Gene therapy, 11(17), 1358-1362 (2004-06-25)
To date, the primary approach to improve the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths or the inclusion of noncationic helper lipids. Here, it is reported that an alternative approach can be...
Boris Tenchov et al.
Chemistry and physics of lipids, 208, 65-74 (2017-10-07)
The non-lamellar phases formed by membrane lipids in diluted aqueous dispersions are mainly represented by the inverted hexagonal phase, HII, and phases of cubic symmetry, among them the bicontinuous cubic phases Pn3m (Q224), Im3m (Q229) and Ia3d (Q230). Here we...
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but...
Boris G Tenchov et al.
Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)
Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for...

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