890899C

Avanti

DODMA

1,2-Dioleyloxy-3-dimethylaminopropane, chloroform solution

Empirical Formula (Hill Notation):
C41H81NO2
CAS号:
分子量:
620.09
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

chloroform solution

packaging

pkg of 1 × 4 mL (890899C-100MG)
pkg of 5 × 4 mL (890899C-500MG)

mfr. no.

Avanti Polar Lipids (890899C)

concentration

25 mg/mL in chloroform

shipped in

dry ice

storage temp.

−20°C

SMILES string

CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

General description

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid. DODMA possesses one double bond in each hydrocarbon tail with tertiary amine group and has a pKa of 7.0.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

Packaging

5 mL Clear Glass Sealed Ampule (890899C-100MG)
5 × 5 mL Clear Glass Sealed Ampule (890899C-500MG)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation
Kubota K, et al.
International journal of nanomedicine, 12(3), 5121-5121 (2017)
Application of DODMA and derivatives in cationic nanocarriers for gene delivery
Chen Z, et al.
Current Organic Chemistry, 20(17), 1813-1819 (2016)
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
Patel S, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 303(3), 91-100 (2019)
Lipofection of plasmid DNA into human mast cell lines using lipid nanoparticles generated by microfluidic mixing
Duguay BA, et al.
Journal of Leukocyte Biology, 104(3), 587-596 (2018)

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