E-070

Supelco

Everolimus-D4 solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Empirical Formula (Hill Notation):
C53H79NO14D4
CAS号:
分子量:
962.25
EC Number:
NACRES:
NA.24
价格与库存信息目前不能提供

Quality Level

grade

certified reference material

CofA

certificate is enclosed in each package

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

mfr. no.

Cerilliant®

concentration

100 μg/mL in acetonitrile

Featured Industry

Pharmaceutical (small molecule)

format

single component solution

storage temp.

−70°C

SMILES string

[2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC(C)\C=C\C=C\C=C(C)\C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CC1OC

InChI

1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/i24D2,25D2

InChI key

HKVAMNSJSFKALM-ULVVDLMCSA-N

General description

A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress® and Certican for use in organ transplantation and Afinitor® for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

Legal Information

Afinitor is a registered trademark of Novartis AG
CERILLIANT is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation
Zortress is a registered trademark of Novartis AG

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Codes

F,Xn

Risk Statement

11-20/21/22-36

Safety Statement

16-36/37

RIDADR

UN 1648 3 / PGII

WGK Germany

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup

技术文章
As new “bath salt” drugs such as methylone, ethylone, mephedrone, butylone and other methcathinone analogs increase in popularity, toxicologists require native and labeled certified reference materials to accurately identify and quantify the new compounds in patient samples.
了解更多
LC-MS/MS is a powerful tool that brings numerous benefits to the clinical sample analysis arena. However, due to the complexity of the instrumentation there are some unique challenges that also accompany these benefits. Even following sample extraction and cleanup, matrix effects from the samples can cause interferences or impact ionization efficiency.
了解更多

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