E-081

Supelco

依替唑仑标准液 CRM 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Empirical Formula (Hill Notation):
C17H15ClN4S
CAS号:
分子量:
342.85
MDL number:
PubChem Substance ID:
NACRES:
NA.24
价格与库存信息目前不能提供

Quality Level

grade

certified reference material

CofA

certificate is enclosed in each package

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

mfr. no.

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland)

concentration

1.0 mg/mL in methanol

format

single component solution

storage temp.

−20°C

SMILES string

CCC1=CC2=C(S1)N3C(CN=C2C4=CC=CC=C4Cl)=NN=C3C

InChI

1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

InChI key

VMZUTJCNQWMAGF-UHFFFAOYSA-N

General description

经认证的溶液标准,可用于临床毒理学、尿液药物测试或法医分析中的LC/MS或GC/MS苯二氮卓测试方法。依替唑仑,商品名为Etilaam、Etizola或Depas,是一种苯二氮卓类似物,可用于失眠、焦虑或惊恐发作的短期治疗。依替唑仑也被作为化合致幻药销售,在欧洲和美国都有药物滥用的案例。

Biochem/physiol Actions

依替唑仑是一种噻吩并二氮杂卓抗焦虑药,与其他苯二氮卓类药物相比具有较低的依赖性。它与其他苯并二氮杂卓类药物的不同之处在于其分子具有噻吩环而不是苯环。它具有抗惊厥、镇静、抗焦虑、遗忘、催眠和肌肉松弛作用。它是通过作用于苯二氮卓受体而发挥作用的。它被用于治疗失眠、中度抑郁和社交焦虑症,并偶尔用于治疗眼睑痉挛和皮肤病变。

Legal Information

CERILLIANT is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

Signal Word

Danger

Target Organs

Eyes

Hazard Codes

F,T

Risk Statement

11-23/24/25-39/23/24/25

Safety Statement

7-16-36/37-45

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

WGK 1

Flash Point(F)

49.5 °F - Not applicable

Flash Point(C)

9.7 °C - Not applicable

Maria Pia De Candia et al.
Clinical therapeutics, 31(12), 2851-2859 (2010-01-30)
Etizolam is an anxiolytic drug with a pharmacologic profile similar to that of the classic benzodiazepines. Neurochemical research suggests that etizolam may have selectivity for the subpopulation of Y-aminobutyric acid type A receptors associated with anxiety (ie, alpha1, beta2, gamma2)....
Masahiro Hirase et al.
European journal of pharmacology, 597(1-3), 46-50 (2008-09-16)
The present study was performed to examine whether or not rebound insomnia is caused by an abrupt withdrawal of benzodiazepine hypnotics and tandospirone in rats. Etizolam and triazolam caused a significant shortening of sleep latency, increase in non-REM sleep time...
Minoru Narita et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 31(4), 739-750 (2005-08-27)
Clinically, it has been reported that chronic pain induces depression, anxiety, and reduced quality of life. The endogenous opioid system has been implicated in nociception, anxiety, and stress. The present study was undertaken to investigate whether chronic pain could induce...
Naoko Tanaka et al.
Soudni lekarstvi, 56(3), 38-39 (2011-09-06)
A fatal poisoning case involving etizolam, phenobarbital, promethazine and chlorpromazine is presented. Quantitative toxicological analysis showed that the concentrations of etizolam, phenobarbital, promethazine and chlorpromazine in the femoral blood were 86 ng/ml, 5082 microg/ml, 0.107 microg/ml and 0.144 microg/ml, respectively...
Akira Namera et al.
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 24(1), 27-34 (2011-04-13)
The immunoassay screening of benzodiazepines in urine is one of the most important methods of drug analysis in clinical and forensic laboratories. We experienced an unusual case of poisoning wherein the result of Triage DOA immunoassay screening was negative, although...

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。