H-089

Supelco

1α,25-二羟基维生素D3标准液 CRM 溶液

5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Empirical Formula (Hill Notation):
C27H44O3
CAS号:
分子量:
416.64
EC 号:
NACRES:
NA.24

质量水平

300

等级

certified reference material

形式

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

manufacturer/tradename

Cerilliant®

浓度

5 μg/mL in ethanol

格式

single component solution

储存温度

−70°C

SMILES string

CC(CCCC(C)(C)O)C1CCC2C(\CCCC12C)=C\C=C3\CC(O)CC(O)C3=C

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-

InChI key

GMRQFYUYWCNGIN-KWJBEKLWSA-N

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一般描述

一种认证加标溶液®适用于在研究及临床环境下关键定量应用,包括:用于LC/UV及LC-MS/MS维生素D检测的对照和校准品制备;作为系统调节/适用性标准品;线性度验证;内部效能测试;OEM用于制备试剂、检测体系开发以及仪器IQ/OQ。这种稳定的定量溶液形式可为用户提供了显著的好处,包括节省材料、提高劳动效率以及使用的便捷性。保存稳定的Snap-N-Spike®形式可帮助实验室免去痛苦的称重操作,并能在使用前将已知浓度的分析物加入到所选择的基质中。
1,α25-二羟基维生素D3是在钙吸收和沉积过程中维生素D3的生物活性形式。它对细胞分化和增殖有广泛的作用,并可调节免疫应答和中枢神经系统功能。最近的研究表明,1α25-二羟基维生素D3可作为化学预防剂抵抗包括前列腺癌和结肠癌在内的多种恶性肿瘤,并显示出了与其他抗癌化合物的协同作用。

应用

1,25-二羟基维生素D3可用作认证参考物质,用于通过液相色谱-串联质谱测定生物体液中的分析物。

法律信息

CERILLIANT is a registered trademark of Cerilliant Corporation
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

象形图

FlameExclamation mark

警示用语:

Danger

危险声明

预防措施声明

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

WGK Germany

WGK 1

闪点(F)

57.2 °F - closed cup

闪点(C)

14 °C - closed cup

分析证书

原产地证书 (CofO)

Sensitive analysis of 1?, 25-dihydroxyvitamin D3 in biological fluids by liquid chromatography--tandem mass spectrometry
Kissmeyer AM and Sonne K
Journal of Chromatography A, 935(1-2), 93-103 (2001)
Zhican Wang et al.
Analytical biochemistry, 418(1), 126-133 (2011-07-26)
Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on health and disease. To that end, we have developed a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
Determination of 1, 25-dihydroxyvitamin D2 and 1, 25-dihydroxyvitamin D3 in human serum using liquid chromatography with tandem mass spectrometry
Fang H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1027, 19-26 (2016)
Nicola Napoli et al.
PloS one, 8(2), e56488-e56488 (2013-02-26)
Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and...
R Volchenkov et al.
Scandinavian journal of immunology, 77(4), 246-254 (2013-02-28)
Dendritic cells (DC) are professional antigen-presenting cells that are capable of both activating immune responses and inducing tolerance. Several studies have revealed efficiency of therapeutic vaccination with tolerogenic DC (tolDC) in inhibition of experimental autoimmunity. The purpose of this study...
技术文章
Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.
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Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components
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Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep
了解更多
This application shows an Ascentis Express F5 provided rapid resolution of the isobaric vitamin D metabolites. MS detection provides the necessary secondary resolution.
了解更多
相关内容
The metabolic role and health implications of the various vitamin D isoforms are of current clinical interest. Therefore, it is important to have an analytical method that will resolve all of the known isoforms with necessary sensitivity and specificity
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