H-090

Supelco

1α,25-二羟基维生素D2标准液 溶液

5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Empirical Formula (Hill Notation):
C28H44O3
CAS号:
分子量:
428.65
EC 号:

质量水平

300

等级

certified reference material

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

manufacturer/tradename

Cerilliant®

浓度

5 μg/mL in ethanol

格式

single component solution

储存温度

−70°C

SMILES string

CC(\C=C\C(C)C(C)(C)O)C1CCC2C(\CCCC12C)=C\C=C3\CC(O)CC(O)C3=C

InChI

1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-

InChI key

ZGLHBRQAEXKACO-WQIUIVEWSA-N

一般描述

准确制备定量引用对于准确评估患者维生素 D 水平非常关键。该认证的加标溶液 ® 适用于研究和临床环境中的关键定量应用,包括:用于制备用于 LC/UV 和 LC-MS/MS 维生素 D 测定的质控品和校准品;作为系统调整/适用性标准;线性验证;内部能力验证;用于 OEM 制备试剂、开发检测试剂盒和仪器 IQ/OQ。稳定、定量的解决方案格式为用户提供了显著的益处,包括节省材料、提高劳动效率和使用方便。保存稳定的Snap-N-Spike®形式可帮助实验室免去痛苦的称重操作,并能在使用前将已知浓度的分析物加入到所选择的基质中。

法律信息

CERILLIANT is a registered trademark of Cerilliant Corporation
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Cerilliant Corporation

象形图

FlameExclamation mark

警示用语:

Danger

危险声明

预防措施声明

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

WGK Germany

WGK 1

闪点(F)

57.2 °F - closed cup

闪点(C)

14 °C - closed cup

分析证书

原产地证书 (CofO)

Rachael M Biancuzzo et al.
The Journal of clinical endocrinology and metabolism, 98(3), 973-979 (2013-02-07)
The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks. Blood from 34 healthy male and female adults...
D R Zimmerman et al.
Archives of biochemistry and biophysics, 392(1), 14-22 (2001-07-27)
Calcitroic acid (1 alpha-hydroxy-23 carboxy-24,25,26,27-tetranorvitamin D(3)) is known to be the major water-soluble metabolite produced during the deactivation of 1 alpha,25-dihydroxyvitamin D(3). This deactivation process involves a series of oxidation reactions at C(24) and C(23) leading to side-chain cleavage and...
Shigeaki Kato et al.
Current opinion in nephrology and hypertension, 16(4), 297-304 (2007-06-15)
Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. Vitamin D-induced transcriptional...
Jared P Reis et al.
Atherosclerosis, 207(2), 585-590 (2009-06-23)
Evidence suggests low vitamin D and elevated parathyroid hormone (PTH) concentrations may increase risk for cardiovascular disease. However, little is known about the association between vitamin D or PTH and subclinical atherosclerosis. This cross-sectional study included 654 community-dwelling older adults...
Sonoko Masuda et al.
Biochimica et biophysica acta, 1761(2), 221-234 (2006-03-07)
While current dogma argues that vitamin D prodrugs require side-chain activation by liver enzymes, recent data suggest that hydroxylation may also occur extrahepatically. We used keratinocytes and recombinant human enzyme to test if the 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) is capable of...
技术文章
Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.
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Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components
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Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep
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This application shows an Ascentis Express F5 provided rapid resolution of the isobaric vitamin D metabolites. MS detection provides the necessary secondary resolution.
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相关内容
The metabolic role and health implications of the various vitamin D isoforms are of current clinical interest. Therefore, it is important to have an analytical method that will resolve all of the known isoforms with necessary sensitivity and specificity
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