Merck
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文件

04-1564

Sigma-Aldrich

Anti-Estrogen Receptor α Antibody, clone F3-A

ascites fluid, clone F3-A, from mouse

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别名:
Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, estrogen receptor 1, estrogen receptor alpha, estrogen receptor alpha delta 4*,5,6,7*/633 isoform, estrogen receptor alpha delta 6,7 isoform
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

F3-A, monoclonal

种属反应性

rat, human, mouse

技术

immunocytochemistry: suitable
western blot: suitable

同位素/亚型

IgG1κ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... ESR1(2099)

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此商品
04-82006-93504-824
抗雌激素受体α抗体 from rabbit, purified by affinity chromatography

06-935

抗雌激素受体α抗体

clone

F3-A, monoclonal

clone

60C, monoclonal

clone

polyclonal

clone

68-4, monoclonal

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

rabbit

species reactivity

rat, human, mouse

species reactivity

rat, pig, mouse, human, bovine

species reactivity

human

species reactivity

mouse, rat, human

UniProt accession no.

P03372

UniProt accession no.

P03372

UniProt accession no.

P06211

UniProt accession no.

P03372

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

一般描述

Estrogen Receptor α (ERα) is a 65 kDa nuclear hormone receptor. This steroid hormone receptor is involved in the regulation of eukaryotic gene expression and affects cellular proliferation and differentiation in target tissues. ERα is a ligand-activated transcription factor and upon being bound by a ligand such as estrogen, a conformational change occurs that allows dimerization and binding to an estrogen response element. When bound to DNA, Estrogen Receptor α can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Two ERs are known, ERα, classically known as ER, and ERβ. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα.

特异性

This antibody recognizes Estrogen Receptor α.

免疫原

Epitope: Unknown
Linear peptide corresponding to human Estrogen Receptor α.

应用

Anti-Estrogen Receptor α Antibody, clone F3-A is a mouse monoclonal antibody for detection of Estrogen Receptor α also known as Estradiol receptor & Nuclear receptor subfamily 3 group A member 1 has been validated in WB, ICC.
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Estrogen Receptor α in A431 cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

质量

Evaluated by Western Blot in mouse ovary tissue lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected Estrogen Receptor α on 10 µg of mouse ovary tissue lysate.

目标描述

~ 67 kDa

外形

Unpurified
Unpurified mouse monoclonal IgG1κ preservative-free ascites.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
Mouse ovary tissue lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Xiaoxiang Cheng et al.
Development, growth & differentiation, 58(3), 327-338 (2016-04-03)
During mouse early embryogenesis, blastomeres increase in number by the morula stage. Among them, the outer cells are polarized and differentiated into trophectoderm (TE), while the inner cells remain unpolarized and give rise to inner cell mass (ICM). TE provides
Willian O Dos Santos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023-08-26)
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been associated with fear memory, a key feature of post-traumatic stress disorder. However, it is currently unknown
Effects of estrogen on vascular inflammation: a matter of timing.
Novella, S; Heras, M; Hermenegildo, C; Dantas, AP
Arteriosclerosis, Thrombosis, and Vascular Biology null
Xiaoman Dai et al.
Neuroendocrinology, 113(7), 756-769 (2023-01-04)
Gonadotropin-releasing hormone (GnRH) is a hypothalamic neuropeptide that plays important roles in the female fertility. Accumulating evidence suggests that ERα present in the astrocytes of the hypothalamus region is essential for production of GnRH. The astrocytes display age-related senescence associated
Vittoria Poli et al.
Nature communications, 9(1), 1024-1024 (2018-03-11)
Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program

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