Merck
所有图片(3)

07-224

Sigma-Aldrich

Anti-phospho-STAT2 (Tyr689) Antibody

Upstate®, from rabbit

别名:
Anti-Anti-IMD44, Anti-Anti-STAT113, Anti-Anti-PTORCH3, Anti-Anti-P113, Anti-Anti-ISGF-3
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

wet ice

Gene Information

human ... STAT2(6773)

一般描述

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia. STAT2 (113 kDa), originally purified from the nuclei of a-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of STAT2 exhibit greater susceptibility to viral infection and altered responses to Type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via assocations with receptor-bound Jak kinases.

特异性

Recognizes STAT2 phosphorylated at tyrosine 689.

应用

Detect phospho-STAT2 (Tyr689) also known as signal transducer & activator of transcription 2 with Anti-phospho-STAT2 (Tyr689) Antibody (rabbit polyclonal antibody), that has been demonstrated to work in WB.
Western Blotting Analysis:
A a representative lot of this antibody detected phospho-STAT2 (Tyr689) in 10 µg of IFN alpha/gamma treated HeLa cell lysate.

Immunoprecipitation Analysis: A representative lot of this antibody immunoprecipitated phospho-STAT2 (Tyr689) from IFN alpha treated HeLa cell lysate.

质量

Evaluated by Western Blotting in HeLa cell lysate.

目标描述

130 kDa

外形

Affinity purified

分析说明

Control
IFN-gamma then IFN-alpha treated HeLa cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

请输入批号搜索分析证书(COA)。

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling.
Bin Gotoh, Kenji Takeuchi, Takayuki Komatsu, Junko Yokoo
Journal of virology null
Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB.
Holloway, Gavan, et al.
Journal of virology, 83, 4942-4951 (2009)
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
Kaoru Takeuchi, Shin-ich Kadota, Makoto Takeda, Naoko Miyajima, Kyosuke Nagata
Febs Letters null
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
Palosaari, H; Parisien, JP; Rodriguez, JJ; Ulane, CM; Horvath, CM
Journal of virology null
A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling.
Paulus, C; Krauss, S; Nevels, M
Proceedings of the National Academy of Sciences of the USA null

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