Merck
All Photos(7)

1.04672

SAFC

胆固醇

EMPROVE® EXPERT, Ph. Eur., BP, JP, NF

Synonym(s):
胆甾-5-烯-3β-醇, 胆甾醇
Empirical Formula (Hill Notation):
C27H46O
CAS Number:
Molecular Weight:
386.65
Beilstein:
1915888
MDL编号:

质量水平

500

生物来源

synthetic

Agency

BP
JP
NF
Ph. Eur.

产品线

EMPROVE® EXPERT

形式

powder

bp

360 °C (lit.)

mp

~141 °C
147-149 °C (lit.)

密度

1.067 g/mL at 25 °C (lit.)

适用性

suitable for (Suitable for formulation and manufacturing use)

application(s)

advanced drug delivery
controlled release
liquid formulation
parenterals
pharmaceutical

储存温度

-10 to -25°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

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一般描述

A GMP-scalable process which yields a high-quality lipid is essential to lipidic drug product development and manufacturing. We are highly specialized in synthesizing top-quality GMP lipids for pharmaceutical applications and gene therapy, focusing on tailored manufacturing to meet your specific needs. We also offer an off-the-shelf catalog with optimized stability, solubility, and handling characteristics.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Cholesterol is a major component of all biological cell membranes and is used as a stabilizer of lipid bilayers in many lipid-based formulations for the delivery of different APIs, such as small molecules and nucleic acids.
Synthetic cholesterol, Ph Eur, BP, JP, NF is ultra-pure and therefore suitable for divers formulations applications. Due to low batch to batch variability, very high purity, and lack of biological components, this product is optimal for highly sensitive applications such as nucleic acid delivery.
With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress. A dual sourcing option is also possible.

生化/生理作用

所有生物膜的主要成分;总脑脂质中含 ~25% 的胆固醇。

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
SyntheChol is a registered trademark of Sigma-Aldrich Co. LLC

免责声明

The substance 1.04672 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

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