1.41544

Parteck^® 聚乙烯醇

EMPROVE^® ESSENTIAL, Ph. Eur.

• 别名: Parteck^® Polyvinyl alcohol, PVA, Polyvinyl alcohol
• 线性分子式: (C₂H₄O)_n
• CAS号: 9002-89-5
• MDL编号: MFCD00081922
• UNSPSC代码: 12352104

属性

• Agency: Ph. Eur.
• 质量水平: 500
• 产品线: EMPROVE^® ESSENTIAL
• 表单: powder
• 应用: pharmaceutical; solid formulation; solubility enhancement
• 储存温度: 15-25°C
• InChI: 1S/C2H4O/c1-2-3/h2-3H,1H2
• InChI key: IMROMDMJAWUWLK-UHFFFAOYSA-N

说明

一般描述

With a lower degree of hydrolysis along the PVA chain, Parteck^® MXP 3-82 Polyvinyl alcohol is especially beneficial in forming strong interac­tions with hydrophobic drug molecules – in the solid state and in solution. Due to this, Parteck^® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologi­cally relevant timescales. As a result, Parteck^® MXP 3-82 Polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules.

应用

Parteck^® MXP 3-82 is a PVA-based excipient that is used in Hot Melt Extrusion for Solubility Enhancement in oral solid dosage forms.

特点和优势

• Superior supersaturation performance via precipitation inhibition
• High thermostability up to 250°C, extending the potential application range
• Stable high drug loads and suitability with a broad range of APIs
• Flexible release kinetics
• Compatible with several downstream processing capabilities, like direct compression, continuous manufacturing, thin film extrusion and 3D printing
• Optimized powder properties for excellent performance in the HME process
• Suitable polymer properties for HME, spray drying and 3D printing processes

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): No data available
• 闪点(°C): No data available