Merck
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23-035-M

Sigma-Aldrich

UbcH5c Protein, active, 10 µg

Active, full length, recombinant human UbcH5c. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.

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别名:
Ubiquitin-conjugating enzyme E2 D3, Ubiquitin-protein ligase D3, Ubiquitin-conjugating enzyme E2-17 kDa 3, UBE2D3
eCl@ss:
32160405
NACRES:
NA.41

生物来源

human

质量水平

100
300

制造商/商品名称

Upstate®

技术

activity assay: suitable

NCBI登记号

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23-025-M23-036-MSRP0442
vibrant-m

23-035-M

UbcH5c Protein, active, 10 µg

vibrant-m

23-025-M

UbcH4 Protein, active, 50 µg

vibrant-m

23-036-M

UbcH6 Protein, active, 10 µg

vibrant-m

SRP0442

UEV1A active human

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

technique(s)

-

NCBI accession no.

NM_181888

NCBI accession no.

NM_003339

NCBI accession no.

NM_003341

NCBI accession no.

NM_021988

Quality Level

100, 300

Quality Level

100

Quality Level

100, 300

Quality Level

-

manufacturer/tradename

Upstate®

manufacturer/tradename

Upstate®

manufacturer/tradename

Upstate®

manufacturer/tradename

-

一般描述

N-terminal HA, 6His-tagged, recombinant human UbcH5c full length, expressed in E.coli.
Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate. The UbcH5 family (UbcH5a, UbcH5b and UbcH5c) have been shown to be the most active class of E2 enzymes in cell extracts and are associated with the control of a number of proteins including the transcriptional regulators p53, IκBα and HIF-1α.

应用

Ubiquitination Cascade Comoponent: E2

外形

Purified using immobilized metal affinity chromatography.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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