343781-M

Sigma-Aldrich

ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses.

别名:
ω-CgTx GVIA, ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem
Empirical Formula (Hill Notation):
C120H182N38O43S6
CAS号:
分子量:
3037.35
MDL number:
价格与库存信息目前不能提供

storage conditions

-20C

General description

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).

Biochem/physiol Actions

Target IC50: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
Primary Target
Voltage-activated N-type Ca2+ channels

Warning

Toxicity: Highly Toxic (H)

Sequence

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
Protti, D.A., et al. 1991. Brain Res.557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
Abe, T., et al. 1986. Neurosci. Lett.71, 203.

Legal Information

Not available for sale outside of the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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