Merck
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420326

Sigma-Aldrich

IRTK激活剂III,DDN- Calbiochem

The IRTK Activator III, DDN modulates the biological activity of IRTK. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):
IRTK激活剂III,DDN- Calbiochem, 5,8-二乙酰氧基-2,3-二氯-1,4-萘醌
Empirical Formula (Hill Notation):
C14H8Cl2O6
Molecular Weight:
343.12
MDL编号:

质量水平

100

测定

≥98% (HPLC)

形式

powder

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
desiccated
protect from light

颜色

pale yellow-green

溶解性

DMSO: 25 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

一种口服可生物利用的二乙酰氧基-萘醌化合物,其直接靶向胰岛素受体酪氨酸激酶(IRTK)结构域,并特异性地增强 IR 激酶活性,而对 IGF-1R 和 EGFR 无效。研究表明,浓度为 5 µM 时可快速磷酸化 IR(Tyr1146 和 Tyr1158/1162/1163)和 IRS-1 ,并选择性激活 CHO-IGF-IR 细胞中的胰岛素信号传导 Akt(Thr473)和 ERK 途径。在正常和糖尿病的 C57BL/6J 小鼠中均可以增强胰岛素的作用,增强分化的 3T3-L1 脂肪细胞的葡萄糖摄取,并降低血糖水平(20 mg/kg,口服)。

包装

25 mg in Glass bottle
用惰性气体包装

警告

毒性:标准处理(A)

重悬

重悬后,等分并冻存(-20°C)。储备液在 -20°C 条件下可稳定保存 6 个月。

其他说明

He, K., et al. 2011.J. Biol. Chem.286, 37379.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Quality

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