Merck
All Photos(1)

483125-M

Sigma-Aldrich

NG-硝基-L-精氨酸甲基酯盐酸盐 - CAS 51298-62-5 - Calbiochem

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Synonym(s):
Nω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl, NG-硝基-L-精氨酸甲基酯盐酸盐 - CAS 51298-62-5 - Calbiochem
Empirical Formula (Hill Notation):
C7H15N5O4 · xHCl
CAS Number:
Molecular Weight:
233.23 (free base basis)
MDL编号:

质量水平

100

测定

≥98% (HPLC)

形式

solid

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

white to off-white

溶解性

water: 50 mg/mL

储存温度

−20°C

InChI

1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1

InChI key

QBNXAGZYLSRPJK-JEDNCBNOSA-N

一般描述

可溶性更高的精氨酸类似物,同时是一种竞争性缓慢可逆的内皮一氧化氮合酶抑制剂(IC50 = 500 nM)。可引起对乙酰胆碱诱导的大鼠主动脉环松弛的长期抑制(IC50 = 400 nM)。
细胞可渗透。可溶性更高的精氨酸类似物,同时是一种竞争性缓慢可逆的eNOS抑制剂(IC50 = 500 nM)。可引起对乙酰胆碱诱导的大鼠主动脉环松弛的长期抑制(IC50 = 400 nM)。

生化/生理作用

靶标IC50:500 nM可抑制eNOS
主要靶标
eNOS

警告

毒性:标准处理(A)

重悬

溶解后,等分并冷冻保存(-20°C)。储备液可在-20°C最长稳定4个月。

其他说明

Baylis, C., et al. 1995.J. Pharmacol.Exp.Ther.274, 1135.
Dawson, V.L., et al. 1991.Proc.Natl.Acad.Sci. USA88, 6368.
Kubes, P., et al. 1991.Proc.Natl.Acad.Sci. USA 88, 4651.
Moncada, S., et al. 1991.Pharmacol.Rev. 43, 109.
Moore, P.K., et al. 1990.Br. J. Pharmacol.99, 408.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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