Merck
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文件

553210

Sigma-Aldrich

Rapamycin

≥95% (HPLC), powder

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别名:
Rapamycin
经验公式(希尔记法):
C51H79NO13
CAS号:
分子量:
914.17
MDL编号:
NACRES:
NA.77

质量水平

检测方案

≥95% (HPLC)

形式

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

clear

溶解性

DMSO: 200 mg/mL
ethanol: 50 mg/mL

运输

ambient

储存温度

−20°C

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此商品
553211390238218710
Rapamycin ≥95% (HPLC), powder

553210

Rapamycin

Sigma-Aldrich

553211

雷帕霉素

Casein Kinase II Inhibitor III, TBCA The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

218710

Casein Kinase II Inhibitor III, TBCA

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 200 mg/mL, ethanol: 50 mg/mL

solubility

-

solubility

DMSO: 5 mg/mL

solubility

DMSO: 10 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL

一般描述

抗真菌剂和免疫抑制剂。选择性抑制哺乳动物雷帕霉素靶蛋白(mTOR),并阻断随后的p70 S6激酶激活(IC50 = 50 pM)。可特异性抑制mTORC1,但可磷酸化Akt(蛋白激酶B)Ser473位的mTORC2则对雷帕霉素不敏感。防止 IGF-II 的翻译激活。还防止静止的T细胞进入细胞周期,但不直接阻止细胞周期进程。研究表明,可抑制随后的信号传导事件,例如p110Rb 磷酸化、p34cdc2激酶激活和细胞周期蛋白A合成。表现出与FK-50 6结合蛋白的强结合力。还据报道在鼠B细胞系中诱导凋亡,抑制淋巴因子诱导的细胞增殖(在G1期),并不可逆地阻滞酿酒酵母细胞(在G1)。另提供5 mM (500 µg/109 µl)雷帕霉素DMSO溶液(货号 553211)和10 mM (1 mg/109 µl)雷帕霉素乙醇溶液(货号553212)。
选择性抑制哺乳动物雷帕霉素靶蛋白(mTOR),并阻断随后的p70 S6激酶激活(IC50 = 50 pM)。可特异性抑制mTORC1,但可磷酸化Akt(蛋白激酶B)Ser473位的mTORC2则对雷帕霉素不敏感。防止 IGF-II 的翻译激活。还防止静止的T细胞进入细胞周期,但不直接阻止细胞周期进程。研究表明,可抑制随后的信号传导事件,例如p110Rb 磷酸化、p34cdc2激酶激活和细胞周期蛋白A合成。表现出与FK-50 6结合蛋白的强结合力。还据报道在鼠B细胞系中诱导凋亡,抑制淋巴因子诱导的细胞增殖(在G1期),并不可逆地阻滞酿酒酵母细胞(在G1期)。

生化/生理作用

主靶
雷帕霉素(mTOR)的哺乳动物靶标
产物不与ATP竞争。
可逆:否
细胞渗透性:否
靶标IC50:50 pM,抑制p70 S6激酶

警告

毒性:标准处理(A)

重悬

复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Chen, T., et al. 2011.Aging Cell.10, 908.
Powell, D.J., et al. 2003.Mol. cell Biol.23, 7794.
Braun, W., et al. 1995.FASEB J.9, 63.
Nielsen, F.C., et al. 1995.Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F.1994.Cell.Immunol. 156, 493.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Morice, W.G., et al. 1993.J. Biol. Chem.268, 3734.
Terada, N., et al. 1993.J. Biol. Chem.268, 12062.
Kuo, J., et al. 1992.Nature 358, 70.
Price, D.J., et al. 1992.Science257, 973.
Heitman, J., et al. 1991.Science253, 905.
Kay, J.E., et al. 1991.Immunology72, 544.
Schreiber, S.L.1991.Science251, 283.
Bierer, B.E., et al. 1990.Proc.Natl.Acad.Sci. USA87, 9231.
Dumont, F.J., et al. 1990.J. Immunol.144, 251.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Carc. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2


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