Merck
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8.54000

Sigma-Aldrich

Dde-Lys(Fmoc)-OH

Novabiochem®

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别名:
Dde-Lys(Fmoc)-OH, N-α-1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-N-ε-Fmoc-L-lysine
Empirical Formula (Hill Notation):
C31H36N2O6
分子量:
532.63

质量水平

产品线

Novabiochem®

检测方案

≥90.0% (acidimetric)
≥96.0% (HPLC)
≥97% (TLC)

形式

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

>70 °C (decomposition)

application(s)

peptide synthesis

官能团

amine

储存温度

15-25°C

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此商品
8.521478.520828.52057
Dde-Lys(Fmoc)-OH Novabiochem®

Sigma-Aldrich

8.54000

Dde-Lys(Fmoc)-OH

Fmoc-D-Lys(Dde)-OH Novabiochem®

Sigma-Aldrich

8.52147

Fmoc-D-Lys(Dde)-OH

Fmoc-Lys(ivDde)-OH Novabiochem®

Sigma-Aldrich

8.52082

Fmoc-Lys(ivDde)-OH

Fmoc-Lys(Dde)-OH Novabiochem®

Sigma-Aldrich

8.52057

Fmoc-Lys(Dde)-OH

assay

≥90.0% (acidimetric), ≥96.0% (HPLC), ≥97% (TLC)

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

assay

≥85.0% (acidimetric), ≥97% (TLC), ≥99.0% (HPLC)

assay

≥90.0% (acidimetric), ≥97.0% (HPLC), ≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

mp

>70 °C (decomposition)

mp

135-145 °C

mp

-

mp

80 °C (decomposes)

functional group

amine

functional group

amine

functional group

amine

functional group

amine

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

-10 to -25°C

storage temp.

15-25°C

一般描述

Quasi-orthogonally-protected Lys derivative. The Fmoc group can be removed selectively by treatment with piperidine; the Dde group is cleaved with 2% hydrazine in DMF [1]. When removing Dde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [2]. Also available Fmoc-Lys(Dde)-OH 852057. This derivative has been employed in Fmoc SPPS to facilitate the introduction of biotin to the side-chain of lysine [3].

Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

[1] B. W. Bycroft, et al. (1993) J. Chem. Soc., Chem. Commun., 778.
[2] B. Rohwedder, et al. (1998) Tetrahedron Lett., 39, 1175.
[3] J. Mack, et al. (1999) Lett. Pept. Sci., 6, 135.

联系

Replaces: 04-12-5201

分析说明

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(157B)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 96.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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商品

Novabiochem® product range has one of the largest collections of orthogonally and quasi-orthogonally protected tri-functional amino acids. These derivatives are useful tools for the synthesis of cyclic and branched peptides and peptides carrying side-chain modifications.

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