Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique.
Chen, W; Liu, J; Zhang, L; Xu, H; Guo, X; Deng, S; Liu, L; Yu, D; Chen, Y; Li, Z
Scientific Reports null
Oscar Diaz-Horta et al.
Journal of molecular medicine (Berlin, Germany), 96(11), 1227-1238 (2018-10-04)
RIPOR2 (previously known as FAM65B) localizes to stereocilia of auditory hair cells and causes deafness when its function is disturbed by mutations. Here, we demonstrate that during the morphogenesis of the hair cell bundle, absence of Ripor2 affects the orientation...
Victoria M Ho et al.
Molecular and cellular neurosciences, 61, 1-12 (2014-05-03)
AMPA-type glutamate receptors mediate fast, excitatory neurotransmission in the brain, and their concentrations at synapses are important determinants of synaptic strength. We investigated the post-transcriptional regulation of GluA2, the calcium-impermeable AMPA receptor subunit, by examining the subcellular distribution of its...
Antoine G Almonte et al.
Journal of neurochemistry, 124(1), 109-122 (2012-11-02)
Protease-activated receptor-1 (PAR1) is an unusual G-protein coupled receptor (GPCR) that is activated through proteolytic cleavage by extracellular serine proteases. Although previous work has shown that inhibiting PAR1 activation is neuroprotective in models of ischemia, traumatic injury, and neurotoxicity, surprisingly...