Merck
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文件

AB2232

Sigma-Aldrich

Anti-Atrial Natriuretic Polypetide Antibody, alpha

from rabbit

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别名:
Atrial natriuretic peptide, natriuretic peptide precursor A, natriuretic peptide precursor A variant 2
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

rat, mouse, human

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... NPPA(4878)

一般描述

Atrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1).

特异性

Cat. # AB2232 recognizes ANP, alpha
May react with dog, cat and cow based on sequence homology.

免疫原

Synthetic Linear Peptide

应用

Non-Lot Specific Tested Application 1:
Immunohistochemistry:
1:50-1:500 on paraffin embedded tissue.

Optimum dilutions need to be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.

质量

Routinely evaluated by western blot

目标描述

~17 kDa

外形

Purified
Format: Purified
Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.

分析说明

Control
Rat Heart

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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