ABE1358

Sigma-Aldrich

Anti-Zinc finger protein 593

from rabbit, purified by affinity chromatography

别名:
ZFP593, Zinc finger protein T86
eCl@ss:
32160702
价格与库存信息目前不能提供

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse

species reactivity (predicted by homology)

rhesus macaque (based on 100% sequence homology), human (based on 100% sequence homology), bovine (based on 100% sequence homology)

application(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

ambient

General description

Zinc finger protein 593 (UniProt: O00488; also known as Zinc finger protein T86) is encoded by the ZNF593 (also known as ZT86) gene (Gene ID: 51042) in human. Zinc fingers are small protein domains wherein zinc plays a structural role contributing to the stability of the domain. Proteins containing zinc fingers are structurally diverse and perform a broad range of functions, including DNA replication and repair, transcription and translation, metabolism, cell proliferation, and apoptosis. Zinc finger domain 593 (ZNF593) belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family and contains a single C2H2 type zinc finger (amino acids 61-85). ZFP593 is largely disordered, with the exception of the zinc finger domain. It displays ubiquitous distribution and has been detected in spleen, prostate, testis, small intestine, and colon and in lower levels in thymus and peripheral blood leukocytes. ZFP593 is shown to negatively modulate the DNA binding activity of Oct-2. It can act either by binding to DNA octamer or by interacting with Oct-2. (Ref.: Srikrishna, S., et al. (2003), Nucleic Acid Res. 31(2): 532-550).

Specificity

This polyclonal antibody detects zinc finger protein 593 in murine embryonic stem cells. It targets an epitope of 14 amino acids from the C-terminus.

Immunogen

KLH-conjugated linear peptide corresponding to 14 amino acids from the C-terminal end of human Zinc finger protein 593.

Application

Research Category
Epigenetics & Nuclear Function
Anti-Zinc finger protein 593 Antibody, Cat. No. ABE1358, is a highly specific rabbit polyclonal antibody that targets Zinc finger protein 593 and has been tested in Immunoprecipitation and Western Blotting.
Western Blotting Analysis: A 1:500 dilution from a representative lot detected Zinc finger protein 593 in mouse embryonic stem cells. (Courtesy of Dr Adrian Bracken from Trinity College, Dublin).

Immunoprecipitation Analysis: 2 ug from a representative lot detected Zinc finger protein 593 in mouse embryonic stem cells. (Courtesy of Dr Adrian Bracken from Trinity College, Dublin).

Quality

Evaluated by Western Blotting in mouse embryonic stem cells.

Western Blotting Analysis: A 1:500 dilution of this antibody detected Zinc finger protein 593 in 10 µg of mouse embryonic stem cells lysate.

Target description

~15 kDa observed. 15.20 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Physical form

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity Purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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