Merck
所有图片(1)

文件

MABF2089

Sigma-Aldrich

Anti-CD28 Antibody, clone 37.51

clone 37.51, from hamster(Syrian)

登录查看公司和协议定价

别名:
T-cell-specific surface glycoprotein CD28
eCl@ss:
32160702

生物来源

hamster (Syrian)

抗体形式

purified antibody

antibody product type

primary antibodies

克隆

37.51, monoclonal

species reactivity

mouse

包装

antibody small pack of 25 μg

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI登记号

UniProt登记号

target post-translational modification

unmodified

Gene Information

mouse ... Cd28(12487)

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
SAB2501381MABF559MABF557
vibrant-m

MABF2089

Anti-CD28 Antibody, clone 37.51

vibrant-m

SAB2501381

Anti-Cd28 antibody produced in goat

clone

37.51, monoclonal

clone

polyclonal

clone

CD28.2, monoclonal

clone

CD28.2, monoclonal

species reactivity

mouse

species reactivity

mouse, pig

species reactivity

human

species reactivity

human

biological source

hamster (Syrian)

biological source

goat

biological source

mouse

biological source

mouse

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

purified antibody

NCBI accession no.

NP_031668.3

NCBI accession no.

-

NCBI accession no.

-

NCBI accession no.

-

Still not finding the right product?  

Give our Product Selector Tool a try.

一般描述

T-cell-specific surface glycoprotein CD28 (UniProt: P31041, also known as CD28) is encoded by the Cd28 gene (Gene ID: 12487) in murine species. CD28 is a single-pass type I membrane protein that exists as a disulfide linked homodimer. In human CD28 is expressed by a majority of T cells in the periphery, including all CD4+ cells and about 50% CD8+ cells. CD28 is synthesized with a signal peptide (aa 1-19), which is subsequently cleaved off in the mature form. It has an extracellular domain (aa 2-150), a transmembrane domain (aa 151-177), and a cytoplasmic domain (aa 178-218). CD28 is involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. It enhances the production of IL-4 and IL-10 in T-cells in conjunction with TCR/CD3 ligation and CD40L co-stimulation. B7-1 (CD80) and B7-2 (CD86) are two known ligands of CD28 on activated B cells and antigen presenting cells (APC). These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction co-stimulatory signaling between the B7 ligands and CD28 is essential for crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

特异性

Clone 37.51 is a Syrian hamster monoclonal antibody that detects CD28 in murine cells.

免疫原

EL-4 T lymphoma cells.

应用

Affects Function Analysis: A representative lot detected CD28 in Affects Function applications (Ulges, A., et. al. (2015). Nat Immunol. 16(3):267-75; Krummel, M.F., et. al. (1995). J Exp Med. 1;182(2):459-65; Brender, C., et. al. (2007) Blood. 1;110(7):2528-36).

Flow Cytometry Analysis: A representative lot detected CD28 in Flow Cytometry applications (Gross, J.A., et. al. (1992). J Immunol. 149(2):380-8; Krummel, M.F., et. al. (1995). J Exp Med. 1;182(2):459-65).

Immunoprecipitation Analysis: A representative lot detected CD28 in Immunoprecipitation applications (Gross, J.A., et. al. (1992). J Immunol. 149(2):380-8).

Western Blotting Analysis: A representative lot detected CD28 in Western Blotting applications (Gross, J.A., et. al. (1992). J Immunol. 149(2):380-8
This syrian hamster monoclonal Anti-CD28, clone 37.51 Antibody, Cat. No. MABF2089 is tested for use in Flow Cytometry, Western Blotting, Immunoprecipitation, and Affects Function, for the detection of CD28.

质量

Evaluated by Flow Cytometry in EL-4 T lymphoma cells.

Flow Cytometry Analysis: 1 µg of this antibody detected CD28 in 1X10E6 EL-4 T lymphoma cells.

目标描述

25.24 kDa calculated.

外形

Format: Purified
Purified syrian hamster monoclonal antibody IgG2-IgG3 in PBS without azide.

其他说明

Concentration: Please refer to lot specific datasheet.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

为方便起见,与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码?

在网站页面上,产品编号会附带包装尺寸/数量一起显示(例如:T1503-25G)。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题?欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

  • 如果您查询到的批号含有填充代码(例如05427ES-021),请输入去除填充代码-021的批号:05427ES。

  • 如果您查询到的批号含有填充代码(例如 STBB0728K9),请输入去除填充代码K9的批号:STBB0728。

未找到您寻找的产品?

部分情况下,可能未在线提供COA。如果搜索不到COA,可在线索取。

索取COA

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门