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MABF519

Sigma-Aldrich

Anti-CD11b Antibody (human/mouse), violetFluor® 450, clone M1/70

clone M1/70, 0.2 mg/mL, violetFluor®

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别名:
Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD antigen CD11b
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rat

质量水平

偶联物

violetFluor® 450

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

M1/70, monoclonal

种属反应性

mouse, human

制造商/商品名称

violetFluor®

浓度

0.2 mg/mL

技术

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

同位素/亚型

IgG2bκ

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... ITGAM(3684)

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此商品
MABF366MABF520MABF512
clone

M1/70, monoclonal

clone

M1/70, monoclonal

clone

M1/70, monoclonal

clone

M1/70, monoclonal

Gene Information

human ... ITGAM(3684)

Gene Information

human ... ITGAM(3684)

Gene Information

human ... ITGAM(3684)

Gene Information

human ... ITGAM(3684)

conjugate

violetFluor® 450

conjugate

Allophycocyanin conjugate

conjugate

Allophycocyanin conjugate

conjugate

APC-Cy7

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

biological source

rat

biological source

rat

biological source

rat

biological source

rat

一般描述

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling throµgh ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

免疫原

Immunogen information for this antibody is proprietary information.

应用

Research Category
Inflammation & Immunology
This rat monoclonal antibody Anti-CD11b (human/mouse), violetFluor 450, clone M1/70 validated for use in IP, IHC, Flow Cytometry & Immunofluorescence for the detection of CD11b.

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 µg of this antibody detected CD11b in one million C57Bl/6 bone marrow cells.

外形

Size Exclusion Chromatography
Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

法律信息

violetFluor is a registered trademark of Tonbo Biotechnologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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