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MABT65

Sigma-Aldrich

Anti-CEACAM1 Antibody, clone 4D1/C2

clone 4D1/C2, from mouse

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别名:
Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1, BGP-1, CD66a
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

4D1/C2, monoclonal

种属反应性

human

技术

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgG1κ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... CEACAM1(634)

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Anti-CEACAM1 Antibody, clone 4D1/C2 clone 4D1/C2, from mouse

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Anti-CEACAM1 Antibody, clone 4D1/C2

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单克隆抗癌胚抗原 小鼠抗

Anti-CEACAM6 Antibody, clone 1H7-4B clone 1H7-4B, from mouse

MABT323

Anti-CEACAM6 Antibody, clone 1H7-4B

Gene Information

human ... CEACAM1(634)

Gene Information

human ... CEACAM5(1048)

Gene Information

human ... CEACAM1(634)

Gene Information

human ... CEACAM6(4680)

clone

4D1/C2, monoclonal

clone

C6G9, monoclonal

clone

2F6, monoclonal

clone

1H7-4B, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

一般描述

CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) is thought to be a member of the immunoglobulin superfamily and is known as an epithelial tumor suppressor and an angiogenic growth factor. It has also been linked to the actin-based cytoskeleton. CEACAM1 is also known as a cellular receptor for a number of human mucosa pathogenic bacteria. The loss of activity of CEACAM1 has been related to the development of colorectal cancer.

免疫原

Epitope: Unknown
Recombinant protein corresponding to human CEACAM1.

应用

Detect CEACAM1 using this Anti-CEACAM1 Antibody, clone 4D1/C2 validated for use in WB, IH.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory to detect CEACAM1 in non-small-cell lung cancer (Dango, S., et al. (2008). Lung Cancer. 60:426-433).

Western Blot Analysis: A representative lot was used by an independent laboratory to detect CEACAM1 in human granulocyte lysate (Bogoevska, V. et al., (2006). Glycobiology. 16(3): 197–209).

Flow Cytometry Analysis: A representative lot was used by an independent laboratory to detect CEACAM1 in human granulocytes by FACS analysis (Bogoevska, V. et al., (2006). Glycobiology. 16(3): 197–209).
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)

质量

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected CEACAM1 in 10 µg of HepG2 cell lysate.

目标描述

~150 kDa observed.
Bands are usually observed at ~120-160 kDa, resulting from different glycosylations (Lauke, H., et al. (2004). Mol. Hum. Reprod. 10(4):247-252).

外形

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HepG2 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Maria L Dupuis et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(9), 357-370 (2015-10-09)
Several lines of evidence show that de novo expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is strongly associated with reduced disease-free survival of patients affected by metastatic melanoma. Previously published investigations report that homophilic interactions between CEACAM1 expressed
Max Klapholz et al.
The Journal of pathology, 257(2), 186-197 (2022-02-05)
Colorectal carcinoma (CRC) is the second leading cause of cancer mortality worldwide. CRC is stratified into two major groups: microsatellite stable (MSS) and microsatellite instability-high (MSI-H). MSS CRC constitutes the majority of cases, has worse overall prognosis, and thus far

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