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OP92

Sigma-Aldrich

抗-BRCA1(Ab-1)小鼠mAb(MS110)

liquid, clone MS110, Calbiochem®

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别名:
抗乳腺癌易感蛋白

生物来源

mouse

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

MS110, monoclonal

形式

liquid

包含

≤0.1% sodium azide as preservative

种属反应性

human

制造商/商品名称

Calbiochem®

储存条件

do not freeze

同位素/亚型

IgG1

运输

wet ice

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... BRCA1(672)

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此商品
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OP92

抗-BRCA1(Ab-1)小鼠mAb(MS110)

vibrant-m

OP93

Anti-BRCA1 (Ab-2) Mouse mAb (MS13)

vibrant-m

OP107

Anti-BRCA1 (Ab-4) Mouse mAb (SD118)

vibrant-m

MABC161

抗-BRCA1抗体,克隆MS13

Gene Information

human ... BRCA1(672)

Gene Information

human ... BRCA1(672)

Gene Information

human ... BRCA1(672)

Gene Information

human ... BRCA1(672)

clone

MS110, monoclonal

clone

MS13, monoclonal

clone

SD118, monoclonal

clone

MS13, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified immunoglobulin

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

一般描述

可识别MCF-7细胞中的~220 kDa BRCA1蛋白。不与血型抗原或生长因子受体(如EGFR)发生交叉反应。根据美国专利号5,753,441和6,162,897的许可证销售。
抗BRCA1(Ab-1),小鼠单克隆,克隆MS110,可识别MCF-7细胞中的~220 kDa BRCA1蛋白。它经过验证可用于冷冻和石蜡切片的WB、IF、IP分析。
通过用指定的免疫原免疫小鼠并将脾细胞与NS1小鼠骨髓瘤细胞融合而产生的纯化小鼠单克隆抗体。可识别~220 kDa BRCA1蛋白。

免疫原

表位:BRCA1的N末端304个氨基酸内
重组人BRCA1

应用

冰冻切片(见应用参考文献)

免疫印迹(2 µg/ml)

免疫荧光(见应用参考文献)

免疫沉淀(见应用参考文献)

石蜡切片(见应用参考文献)

包装

请参考特定浓度批号的标签。

警告

毒性:标准处理(A)

外形

溶于50 mM磷酸钠缓冲液(pH 7.5),含0.2%明胶。

分析说明

阳性对照
MCF7细胞

其他说明

Scully, R., et al. 1996.Science272, 123.
Gudas, J.M., et al. 1996.Cell Growth Differ.7, 717.
Vaughn, J.P., et al. 1996.Cell Growth Differ.7, 711.
Goldgar, D.E. and Reilly, P.R.1995.Nat. Genet.11, 113.
Merajver, S.D., et al. 1995.Clin. Can.Res.1, 539.
Merajver, S.D., et al. 1995.Nat. Genet.9, 439.
Struewing, J.P., et al. 1995.Nat. Genet.11, 198.
Thompson, M.E., et al. 1995.Nat. Genet.9, 444.
Futreal, P.A., et al. 1994.Science266, 120.
Miki, Y., et al. 1994.Science266, 66.
Wilson, C.A., et al. 1999.Nat. Genet.21, 236.
在单个系统中,应对抗体进行滴定以获得最佳结果。

法律信息

根据美国专利号5,753,441和6,162,897的许可证销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Pierre Thouvenot et al.
Journal of cell science, 129(23), 4366-4378 (2016-11-02)
Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutations found in human
Geon Kim et al.
Oncology letters, 17(6), 5023-5029 (2019-06-13)
Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. When BRCA1 is mutated or altered, DNA
J Xu et al.
International journal of oncology, 34(4), 939-949 (2009-03-17)
BRCA1 dysfunction is associated with hormone-responsive cancers. We have identified a consensus SUMO modification site in the amino-terminal region of BRCA1/1a/1b proteins and the mutation in this potential SUMO acceptor site (K 109 to R) impaired their ability to bind
Nathalie van den Tempel et al.
Cancers, 11(1) (2019-01-18)
The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract
Hong Wang et al.
Cancer research, 70(15), 6258-6267 (2010-07-16)
The tumor suppressor BRCA1 is a nuclear shuttling protein. However, the role of BRCA1 localization in the control of its functions remains to be elucidated. Given the central role of BRCA1 in DNA damage repair, we hypothesized that depletion of

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