Merck
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SCC064

Sigma-Aldrich

LX-2 人肝星状细胞系

The LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them a highly suitable model of human hepatic fibrosis.

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别名:
HSC, Perisinusoidal cells, Ito cells, Hepatic lipocytes, Hepatic pericytes
eCl@ss:
32011203
NACRES:
NA.75

生物来源

human

质量水平

technique(s)

cell culture | stem cell: suitable

运输

liquid nitrogen

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此商品
SCC069SCC043SCC049
LX-2 Human Hepatic Stellate Cell Line The LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them a highly suitable model of human hepatic fibrosis.

Sigma-Aldrich

SCC064

LX-2 人肝星状细胞系

C28/I2 Human Chondrocyte Cell Line C28/I2 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.

Sigma-Aldrich

SCC043

C28/I2 人软骨细胞系

technique(s)

cell culture | stem cell: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | stem cell: suitable

shipped in

liquid nitrogen

shipped in

ambient

shipped in

ambient

shipped in

liquid nitrogen

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

一般描述

在慢性酒精中毒、乙型和丙型肝炎、脂肪性肝病、肥胖症和糖尿病等疾病中,肝星状细胞被激活为成纤维性肌成纤维细胞样细胞后,是负责肝纤维化的主要细胞类型。需要准确概括其体内表型的可再生细胞培养模型,特别是对于人类研究。

LX-2是通过用SV40大T抗原永生化原代人肝星状细胞,然后在低血清培养基条件选择性培养早期传代细胞而产生的。

Xu等人建立了永生化LX-2,以克服培养物的可变性问题,并提供稳定且无限的同质人肝星状细胞来源。这些细胞系已被广泛表征,并保留了细胞因子信号传导,神经元基因表达,类视黄醇代谢和纤维形成的关键特征,使其非常适合基于培养的人肝纤维化研究。

应用

研究类别
传染病

炎症&免疫学

干细胞研究

组分

1)≥1X106 活性LX-2人肝星状细胞:(目录号SCC064)。储存在液氮中。

质量

• 每瓶含有≥ 1X106 个活细胞。
•通过PCR检测细胞,对甲型、乙型、丙型肝炎和HIV-1 & 2型病毒呈阴性。
•细胞对支原体污染呈阴性。

储存及稳定性

LX-2细胞应储存在液氮中。细胞可以培养至少10代,而不会显著影响细胞标志物的表达和功能。LX-2细胞已成功扩增超过培养的第50代。

其他说明

根据产品文件中详述的“学术使用协议”的条款,本产品预期仅用于销售和销售给学术机构,以供内部学术研究使用。有关任何其他用途的信息,请联系licensing@emdmillipore.com。

免责声明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

储存分类代码

10 - Combustible liquids

WGK

WGK 1


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Oleic acid suitable for cell culture, BioReagent

Sigma-Aldrich

O1383

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Interactions between glycans and glycan-binding proteins (GBPs) consist of weak, noncovalent, and transient binding events, making them difficult to study in live cells void of a static, isolated system. Furthermore, the glycans are often presented as protein glycoconjugates, but there
Ming-Feng Chen et al.
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Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, cell cycle arrest and apoptosis induction in several cancer
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Amniotic membranes (AM) have anti-fibrotic activity. Exosomes (nano-sized vesicles) function as conduits for intercellular transfer and contain all the necessary components to induce the resolution of fibrosis. In this study, we tested the hypothesis that the anti-fibrotic activity of AM

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