Merck
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SCC065

Sigma-Aldrich

HL-1 心肌细胞系

HL-1 Cardiac Muscle Cell Line has been extensively characterized and is a valuable model system to address questions of cardiac biology at the cellular & molecular levels.

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别名:
HL-1 Cardiomyocyte Cell Line, HL-1 Atrial Muscle Cell Line
eCl@ss:
32011203
NACRES:
NA.81

生物来源

mouse

质量水平

technique(s)

cell based assay: suitable
cell culture | mammalian: suitable

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SCC116SCC067SCC295
HL-1 Cardiac Muscle Cell Line HL-1 Cardiac Muscle Cell Line has been extensively characterized and is a valuable model system to address questions of cardiac biology at the cellular & molecular levels.

Sigma-Aldrich

SCC065

HL-1 心肌细胞系

HMC-1.1 Human Mast Cell Line HMC-1.1 human mast cell line is a variant subline of the HMC-1 cell line and possesses the V560G KIT mutation.

Sigma-Aldrich

SCC067

HMC-1.1 人肥大细胞系

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

一般描述

HL-1心肌细胞系是永生化的小鼠心肌细胞系,能够连续分裂并自发收缩,同时保持分化的心脏表型。 HL-1可以连续传代,而不会失去其分化的心肌细胞表型,包括形态、生化和电生理特性。HL-1细胞已用于研究正常心肌细胞在信号传导、电、代谢和转录调控方面的功能,以及解决诸如缺氧、高血糖-高胰岛素血症、细胞凋亡和缺血再灌注等病理状况。

HL-1系源自从成年雌性C57BL/6J小鼠切除的AT-1皮下肿瘤。亲本AT-1系最初源自在转基因小鼠中生长的心房肿瘤,其中SV40大T抗原的表达通过心房利钠因子(ANF)启动子靶向心房心肌细胞。

细胞系描述

心肌细胞

应用

根据产品文件中详述的“学术使用协议”条款,本产品预期仅用于销售和销售给学术机构,以供内部学术研究使用。有关任何其他用途的信息,请联系licensing@emdmillipore.com。
研究类别
心脏

心血管疾病

毒性

质量

• 每瓶含有≥ 1X106 个活细胞。
•Charles River动物诊断服务通过小鼠必要透明面板PCR面板对细胞进行传染病检测,结果为阴性。
•细胞对支原体污染呈阴性。
•功能测试:基于Fluo-8钙染料的荧光检测细胞内钙的变化

储存及稳定性

HL-1心肌细胞系应保存在液氮中。在初始解冻后,细胞可以培养至少10代,而不会显著影响细胞标志物的表达和功能。

免责声明

除非在产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得对人或动物用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用。

本产品含有转基因生物(GMO)。在欧盟范围内,转基因物种分别受欧洲议会和理事会的2001/18 /EC和2009/41/EC指令及其成员国中国家所实施规范的约束。这项法律规定{HCompany}有义务要求您提供某些信息,以及有关处理 GMO 的机构的信息。请点击这里,获得最终用户声明(EUD)表格。

储存分类代码

10 - Combustible liquids

WGK

WGK 2


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IUBMB life, 72(8), 1737-1746 (2020-05-01)
Cardiac hypoxia plays a significant role in various types of heart disease, and improper treatment of hypoxia often leads to myocardial cell damage or even death. Transcriptome profiling and open chromatin mapping have been used as powerful tools to understand
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Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio-temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing its development
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We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage. HL-1 cells can be serially passaged, yet they maintain the ability to contract and retain differentiated cardiac morphological, biochemical, and electrophysiological properties.
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Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal adverse effects, and thus, the identification of underlying mechanisms for developing strategies to overcome it has clinical importance. This study aimed to investigate whether microbiota-host interactions contribute to PD-1/PD-L1 inhibitor-related
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