Merck
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SCC148

Sigma-Aldrich

MB49小鼠膀胱癌细胞系

MB49 mouse urothelial carcinoma cell line is widely used as an in vitro and in vivo model of bladder cancer.

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别名:
MB-49
eCl@ss:
32011203
NACRES:
NA.81

生物来源

mouse

质量水平

technique(s)

cell culture | mammalian: suitable

运输

ambient

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SCC070SCC072SCC173
technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

shipped in

ambient

shipped in

liquid nitrogen

shipped in

liquid nitrogen

shipped in

ambient

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

一般描述

MB49细胞来自C57BL/Icrf-a’小鼠膀胱上皮细胞,在长期原代培养的第二天经化学致癌物7, 12-二甲苯[a]蒽(DMBA)单独处理24小时后转化。 经证实,移植到同基因鼠体内的转化细胞可诱发癌症。 而对父系起源,核型分析表明Y染色体在所分析的细胞中会100%丢失。 这种异常是人类膀胱癌的常见早期事件。 最近的一项研究表明,MB49细胞再现了膀胱肿瘤生长中性别差异的关键特征。 MB49植入小鼠后,雄性小鼠的肿瘤明显大于雌性小鼠。 在双氢睾酮的作用下,MB49细胞呈剂量依赖性增殖增强。 相反,MB49细胞对妊娠激素、人绒毛膜促性腺激素(hCG)无反应。MB49细胞表现为MHC-I类和II类分子的低表达或不表达。 然而,IFN-暴露后,MHC I类和II类表达显著上调

质量

• 每小瓶含有≥ 1X106个活细胞。
• Charles River动物诊断服务通过小鼠Essential CLEAR小组对细胞进行传染病检测,结果为阴性。
• 通过Charles River动物诊断服务的污染透明小组评估,证实细胞为小鼠来源,对大鼠、中国仓鼠、金色黄叙利亚仓鼠、人和非人灵长类动物(NHP)的种间污染物呈阴性。
• 细胞对支原体污染呈阴性

其他说明

根据产品文件中详述的“学术使用协议”的条款,本产品预期仅用于销售和销售给学术机构,以供内部学术研究使用。有关任何其他用途的信息,请联系licensing@emdmillipore.com。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable


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Dominik Gulyás et al.
PloS one, 17(7), e0270802-e0270802 (2022-07-09)
The basis of the antitumor immunotherapy, of which the purpose is the stimulation of the immune system. We have used two of the Pathogen Associated Molecular Patterns: unmethylated CpG oligonucleotide, a ligand of Toll-like receptor 9 (TLR9), and lipopolysaccharide (LPS)
Vanessa Bellat et al.
Cancer research, 82(7), 1409-1422 (2022-01-19)
The standard treatment of nonmuscle invasive bladder cancer (NMIBC) is transurethral resection of the tumors, followed by intravesical therapy (IT), which comprises a direct instillation of a solution of Bacillus Calmette-Guérin vaccine or chemotherapy into the bladder. However, the recurrence
Mathieu Rouanne et al.
The Journal of clinical investigation, 132(12) (2022-05-04)
Patients with high-risk, nonmuscle-invasive bladder cancer (NMIBC) frequently relapse after standard intravesical bacillus Calmette-Guérin (BCG) therapy and may have a dismal outcome. The mechanisms of resistance to such immunotherapy remain poorly understood. Here, using cancer cell lines, freshly resected human
Guangchuan Wang et al.
Cancer discovery, 10(12), 1912-1933 (2020-09-06)
Immune checkpoint blockade (ICB) has shown remarkable clinical efficacy in several cancer types. However, only a fraction of patients will respond to ICB. Here, we performed pooled mutagenic screening with CRISPR-mediated genetically engineered mouse models (CRISPR-GEMM) in ICB settings, and
Zheng Zhu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(21), 4820-4831 (2022-08-04)
Immune checkpoint inhibitors (ICI) in general have shown poor efficacy in bladder cancer. The purpose of this project was to determine whether photodynamic therapy (PDT) with bladder cancer-specific porphyrin-based PLZ4-nanoparticles (PNP) potentiated ICI. SV40 T/Ras double-transgenic mice bearing spontaneous bladder

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