Merck
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SCC187

Sigma-Aldrich

MEC1 Mouse Embryonic Epicardial Cell Line

MEC1 mouse embryonic epicardial cell line is a useful model for cardiac developmental biology studies.

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eCl@ss:
32011203

生物来源

mouse

technique(s)

cell culture | mammalian: suitable

运输

ambient

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此商品
SCC065SCC109SCC152
HL-1 Cardiac Muscle Cell Line HL-1 Cardiac Muscle Cell Line has been extensively characterized and is a valuable model system to address questions of cardiac biology at the cellular & molecular levels.

Sigma-Aldrich

SCC065

HL-1 心肌细胞系

technique(s)

cell culture | mammalian: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

shipped in

ambient

shipped in

-

shipped in

dry ice

shipped in

ambient

一般描述

Heart development is guided by mitogenic factors secreted by the epicardium, a cell layer that overlays the myocardium in the mid-gestation embryonic heart. Despite the importance of these factors in directing cardiomyocyte proliferation and morphogenesis, they are not well-characterized. Cellular models of the embryonic epicardium are thus essential for gaining a comprehensive understanding of the mechanisms of cardiac development.
MEC1 is an immortalized mouse embryonic epicardial cell line that does not express myocardial or endothelial cell lineages. MEC1 cells retain the morphology of early primary epicardial cells and express epicardium-specific markers including epicardin (Tcf21), Tbx18 and cytokeratin-18. MEC1 cells localized ZO-1 and beta-catenin in adherens junctions at the cell membrane and possessed organized actin cytoskeletal filaments. The native physiological features of the MEC1 cell line contribute to its suitability for addressing a wide range of questions in cardiac developmental biology.

Source:
Non-GMO. MEC1 is a stable cell line derived from primary cultures of E13.5 wild-type embryonic ventricles of an ICR/CD1 strain mouse. Individual colonies that retained early epicardial cell morphology underwent several iterative rounds of subcloning.

Reference:
Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov HM (2011). IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development 138(9): 1795-17805.

细胞系描述

Epicardial Cells

应用

MEC1 mouse embryonic epicardial cell line is a useful model for cardiac developmental biology studies.
Research Category
Cardiac
Research Sub Category
Developmental Signaling
This product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.

质量

• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination

储存及稳定性

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable


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Jihyun Jang et al.
Circulation research, 131(2), 151-164 (2022-06-21)
Establishment of the myocardial wall requires proper growth cues from nonmyocardial tissues. During heart development, the epicardium and epicardium-derived cells instruct myocardial growth by secreting essential factors including FGF (fibroblast growth factor) 9 and IGF (insulin-like growth factor) 2. However
Julia Junghof et al.
NPJ Regenerative medicine, 7(1), 14-14 (2022-02-04)
The epicardium is a mesothelial layer covering the myocardium serving as a progenitor source during cardiac development. The epicardium reactivates upon cardiac injury supporting cardiac repair and regeneration. Fine-tuned balanced signaling regulates cell plasticity and cell-fate decisions of epicardial-derived cells

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