Merck
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SCC286

Sigma-Aldrich

CUTLL1 Human T-cell Lymphoblastic Lymphoma Cell Line

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生物来源

human

包装

vial of >1X10⁶ cells

manufacturer/tradename

Millipore

生长模式

N/A

technique(s)

cell culture | mammalian: suitable

运输

dry ice

储存温度

≤ − 140°C

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SCC291SCC483SCC421
manufacturer/tradename

Millipore

manufacturer/tradename

Sigma-Aldrich

manufacturer/tradename

Millipore

manufacturer/tradename

Millipore

growth mode

N/A

growth mode

N/A

growth mode

N/A

growth mode

N/A

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable, cell migration: suitable

technique(s)

cell culture | mammalian: suitable

shipped in

dry ice

shipped in

dry ice

shipped in

liquid nitrogen

shipped in

dry ice

storage temp.

≤ − 140°C

storage temp.

≤ − 140°C

storage temp.

−196°C

storage temp.

≤ − 140°C

应用

T-cell acute lymphoblastic lymphoma (T-ALL) is a rare but aggressive form of non-Hodgkin lymphoma, with a high relapse rate and poor long-term survival (1). The majority of T-cell lymphoblastic leukemias and lymphomas harbors activating mutations in the NOTCH1 gene, a key signaling component required for T-cell development (2). Drugs targeting the Notch pathway are thus promising avenues for treatment of T-cell lymphoblastic leukemias. Lack of response of human T-ALL cell lines to Notch inhibitors has hampered the clinical applicability of these models.

CUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t(7;9)(q34;q34) chromosomal translocation resulting in expression of a TCRB-NOTCH1 fusion transcript and aberrant Notch signaling (3). CUTLL1 cells demonstrate high sensitivity to gamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T-cells including CD3, CD4, CD8 and TCRαα (3).

Source:
The CUTLL1 cell line was established from pleural effusion of a relapsed 14-year-old male patient suffering from T-cell lymphoblastic lymphoma (2)

References:
1. Cancer J. 2012; 18(5): 432-8.
2. Science 2004; 306(5694): 269-71.
3. Leukemia 2006; 20(7): 1279-87.

特点和优势

The CUTLL1 cell line is a valuable and clinically relevant model for T-cell lymphoblastic lymphoma.

储存及稳定性

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

其他说明

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

免责声明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


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