Merck
所有图片(3)

410225

Sigma-Aldrich

甘氨酸

ACS reagent, ≥98.5%

别名:
乙氨酸, 氨基乙酸, 氨基醋酸
线性分子式:
NH2CH2COOH
CAS号:
分子量:
75.07
Beilstein:
635782
EC 号:
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.21

质量水平

200

等级

ACS reagent

测定

≥98.5%

形式

crystals
powder or granules

杂质

H2SO4, passes test (darkened)
Hydrolyzable subsances, passes test

灼烧残渣

≤0.1%

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

痕量阴离子

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

痕量阳离子

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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应用

甘氨酸用于全细胞膜片钳记录,以测量NMDA(N-甲基-D-天冬氨酸)内向电流。它还用作结晶学中的模型有机系统,展示新型声学雾化平台。

包装

50, 250 g in poly bottle

生化/生理作用

甘氨酸是非必需氨基酸。通过细胞膜的钙内流由甘氨酸门控通道介导。甘氨酸参与卟啉、嘌呤和丝氨酸的合成。它还可作为谷氨酸与NMDA(N-甲基-D-天冬氨酸)受体结合的竞争性激动剂。在快速增殖的癌细胞中,由于对氨基酸的需求增加,甘氨酸合成可能会增加。
脊髓中的抑制性神经递质,NMDA 受体的变构调节剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

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