Merck
所有图片(2)

C1357

Sigma-Aldrich

胆钙化醇

meets USP testing specifications

别名:
活化7-脱氢胆固醇, (+)-维生素 D3, 胆骨化醇, 活化7-脱氢胆甾醇
Empirical Formula (Hill Notation):
C27H44O
CAS号:
分子量:
384.64
Beilstein:
2339331
EC 号:
MDL编号:
eCl@ss:
34058003
PubChem化学物质编号:
NACRES:
NA.21

质量水平

200

Agency

USP/NF
meets USP testing specifications

测定

97.0-103.0%

形式

crystalline

颜色

white

mp

83-86 °C (lit.)

application(s)

pharmaceutical (small molecule)

储存温度

2-8°C

SMILES string

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Gene Information

human ... VDR(7421)

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相关类别

一般描述

胆钙化醇(维生素D3)是一种在皮肤中产生的脂溶性类固醇。

应用

胆钙化醇已被用于:
  • 诱导小鼠动脉中膜钙化 (arterial medial calcification,AMC)
  • 研究其在肥胖和胰岛素抵抗小鼠模型中对血管钙化(VC)相关血管重塑的影响(ob / ob小鼠)
  • 研究其对单层培养物中RWPE2-W99细胞锚定依赖性生长的影响

包装

25 g in glass bottle
1 g in ampule
250 mg in ampule

生化/生理作用

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

更多文件

Quotes and Ordering

Expansive vascular remodeling and increased vascular calcification response to cholecalciferol in a murine model of obesity and insulin resistance
Carmo LS, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 39(2), 200-211 (2019)
Cholecalciferol (vitamin D 3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells
Tokar EJ and Webber MM
Clinical & Experimental Metastasis, 22(3), 275-284 (2005)
Chronic Kidney Disease-Mineral and Bone Disorder
Handbook of Dialysis Therapy, 685-697 (2016)
Runx2 expression in smooth muscle cells is required for arterial medial calcification in mice
Lin ME, et al.
The American Journal of Pathology, 185(7), 1958-1969 (2015)
Stefan Pilz et al.
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values

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