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Merck
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主要文件

E2503004

依托咪酯杂质B

European Pharmacopoeia (EP) Reference Standard

别名:

Methyl 1-[(1RS)-1-phenylethyl]-1H-imidazole-5-carboxylate

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About This Item

经验公式(希尔记法):
C13H14N2O2
CAS号:
分子量:
230.26
MDL號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

etomidate

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

[n]2(cncc2C(=O)OC)C(C)c1ccccc1

InChI

1S/C13H14N2O2/c1-10(11-6-4-3-5-7-11)15-9-14-8-12(15)13(16)17-2/h3-10H,1-2H3

InChI 密鑰

FHFZEKYDSVTYLL-UHFFFAOYSA-N

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Etomidate impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Skull and crossbonesEnvironment

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Heikki Minn et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 45(6), 972-979 (2004-06-08)
Our aim was to evaluate the use of PET with (11)C-metomidate and (18)F-FDG for the diagnosis of adrenal incidentalomas. Twenty-one patients underwent hormonal screening before dynamic imaging of the upper abdomen with (11)C-metomidate, and for 19 of these 21 patients
J Hennings et al.
Langenbeck's archives of surgery, 395(7), 963-967 (2010-07-21)
To evaluate whether dexamethasone suppression treatment can improve (11) C-metomidate positron emission tomography (MTO-PET) detection of small adrenocortical adenomas in primary aldosteronism (PA). Eleven patients with proven PA and two patients with non-hyperfunctioning adrenocortical incidentalomas and small adrenocortical tumours observed
Joakim Hennings et al.
The Journal of clinical endocrinology and metabolism, 91(4), 1410-1414 (2006-01-13)
Adrenal incidentalomas are common findings necessitating extensive laboratory work-up and repetitive radiological examinations. Positron emission tomography (PET) using (11)C-labeled metomidate (MTO) has previously been described as a tool for specific adrenocortical imaging. We evaluated 212 MTO-PET examinations in 173 patients
Barbro Eriksson et al.
Annals of the New York Academy of Sciences, 970, 159-169 (2002-10-17)
Positron emission tomography (PET) supplies a range of labeled compounds to be used for the characterization of tumor biochemistry. Some of these have proved to be of value for clinical diagnosis, treatment follow up, and clinical research. The first routinely
Georg Zettinig et al.
European journal of nuclear medicine and molecular imaging, 31(9), 1224-1230 (2004-06-16)
(11)C-metomidate (MTO), a marker of 11beta-hydroxylase, has been suggested as a novel positron emission tomography (PET) tracer for adrenocortical imaging. Up to now, experience with this very new tracer is limited. The aims of this study were (1) to evaluate

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