Merck
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G4251

Sigma-Aldrich

L -还原型谷胱甘肽

≥98.0%

Synonym(s):
5-L-谷氨酰-L-半胱氨酰甘氨酸, GSH
Linear Formula:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS Number:
Molecular Weight:
307.32
Beilstein:
1729812
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.26

质量水平

300

测定

≥98.0%

形式

powder

颜色

white

mp

192-195 °C (dec.) (lit.)

application(s)

detection

储存温度

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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Related Categories

Amino Acid Sequence

γ-Glu-Cys-Gly

应用

还原的L-谷胱甘肽(GSH)已用于洗脱缓冲液用于通过使用谷胱甘肽-琼脂糖微珠进行GST(谷胱甘肽S-转移酶)融合蛋白的洗脱。它已用于绘制GSH分析物的标准曲线。
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。

包装

10 mg in glass bottle
300 mg in poly bottle
1, 5, 10, 25, 50, 100, 250, 500 g in poly bottle

生化/生理作用

在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制,它可具有降低抗癌剂效用的奇异效果。
还原的L-谷胱甘肽(GSH)是一种硫醇化合物,并与分解代谢和转运相关。血浆GSH的水平与帕金森症、阿尔兹海默症、糖尿病、黄斑退化和HIV(人类免疫缺陷病毒)疾病相关。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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