G4251

L -还原型谷胱甘肽

≥98.0%

• Synonym(s): γ-L-谷酰基-L-半胱氨酰-甘氨酸, GSH
• Linear Formula: H₂NCH(CO₂H)CH₂CH₂CONHCH(CH₂SH)CONHCH₂CO₂H
• CAS Number: 70-18-8
• Molecular Weight: 307.32
• Beilstein: 1729812
• EC 号: 200-725-4
• MDL编号: MFCD00065939
• PubChem化学物质编号: 24895164
• NACRES: NA.26

Properties

• 质量水平: 300
• 检测方案: ≥98.0%
• 形式: powder
• 颜色: white
• mp: 192-195 °C (dec.) (lit.)
• application(s): detection
• 储存温度: 2-8°C
• SMILES string: N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
• InChI key: RWSXRVCMGQZWBV-WDSKDSINSA-N

Description

Amino Acid Sequence

γ-Glu-Cys-Gly

一般描述

Glutathione (GSH) is a ubiquitous molecule found in many cells and tissues. The three amino acids present in GSH are glycine, cysteine, and glutamic acid.

应用

还原的L-谷胱甘肽（GSH）已用于洗脱缓冲液用于通过使用谷胱甘肽-琼脂糖微珠进行GST（谷胱甘肽S-转移酶）融合蛋白的洗脱。它已用于绘制GSH分析物的标准曲线。

可在5-10 mM下用于从谷胱甘肽琼脂糖洗脱谷胱甘肽S-转移酶(GST)。

生化/生理作用

Glutathione (GSH) forms conjugates with various metabolites and xenobiotics. It acts as an important co-factor for various enzymes. GSH is involved in many metabolic and signaling pathways. Glutathione functions as a thiol buffer for cellular proteins like thioredoxins and metallothioneins. GSH is also involved in the regeneration of antioxidants like tocopherols and ascorbate.

作为内源性抗氧化剂在减少细胞代谢和呼吸爆发期间生成的活性氧方面发挥重要作用。 谷胱苷肽S-转移酶催化异生素、白三烯和其他亲电子分子生成谷胱苷肽硫醚。 谷胱苷肽也和蛋白质半胱氨酸残基形成二硫键。 经由这些机制，它会产生降低抗癌药功效的逆反效应(paradoxical effect)。

Safety Information

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(F): Not applicable
• 闪点(C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)