K4000
卡那霉素 硫酸酯 来源于卡那霉素链霉菌
Animal Component-free
别名:
卡那霉素 A, 卡那霉素碱 硫酸盐
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关于此项目
经验公式（希尔记法）:
C18H36N4O11 · H2O4S
化学文摘社编号:
分子量:
582.58
EC號碼:
MDL號碼:
分類程式碼代碼:
51281654
PubChem物質ID:
NACRES:
NA.76
生物源
Streptomyces kanamyceticus
品質等級
形狀
powder
效力
≥750 μg per mg (dry basis)
顏色
white to off-white
溶解度
H2O: 50 mg/mL, clear, colorless to faintly yellow
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
作用方式
protein synthesis | interferes
SMILES 字串
OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI 密鑰
OOYGSFOGFJDDHP-KMCOLRRFSA-N
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一般說明
Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.
應用
Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:
- in the research of bacterial antibiotic resistance
- in the research on the effect of different antibiotics on bud regeneration
生化／生理作用
作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
特點和優勢
High quality antibiotic suitable for mulitple research applications
準備報告
Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
其他說明
For additional information on our range of Biochemicals, please complete this form.
訊號詞
Danger
危險聲明
危險分類
Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 2
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Didrik H Grevskott et al.
Frontiers in microbiology, 8, 24-24 (2017-02-06)
The mechanisms for the development and spread of antibacterial resistance (ABR) in bacteria residing in environmental compartments, including the marine environment, are far from understood. The objective of this study was to examine the ABR rates in Escherichia coli and
Effect of gelling agents and antibiotics on adventitious bud regeneration from In vitro leaves of pear
Chevreau et al.
In Vitro Cellular & Developmental Biology. Plant, 33, 173?179-173?179 (1997)
J Yuyang Lu et al.
Cell reports, 30(10), 3296-3311 (2020-03-12)
Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a striking association between repeat subtypes and gene function. SINE, L1, and low-complexity repeats demarcate distinct functional categories of genes and may dictate the time and level of gene
Benjamin Bardiaux et al.
Structure (London, England : 1993), 27(7), 1082-1093 (2019-05-06)
Bacterial type 4a pili are dynamic surface filaments that promote bacterial adherence, motility, and macromolecular transport. Their genes are highly conserved among enterobacteria and their expression in enterohemorrhagic Escherichia coli (EHEC) promotes adhesion to intestinal epithelia and pro-inflammatory signaling. To
Mitsutaka Kitano et al.
Antimicrobial agents and chemotherapy, 58(8), 4795-4803 (2014-06-11)
Highly pathogenic avian influenza A (H5N1) viruses cause severe and often fatal disease in humans. We evaluated the efficacy of repeated intravenous dosing of the neuraminidase inhibitor peramivir against highly pathogenic avian influenza virus A/Vietnam/UT3040/2004 (H5N1) infection in cynomolgus macaques.
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