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M9140

Sigma-Aldrich

亚甲蓝

certified by the Biological Stain Commission

别名:
亚甲基蓝, Basic Blue 9, 3,7-双(二甲基氨基)吩噻嗪-5-鎓氯化物
Empirical Formula (Hill Notation):
C16H18ClN3S · xH2O
CAS号:
分子量:
319.85 (anhydrous basis)
颜色索引号:
52015
Beilstein:
3599847
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.47

质量水平

200

等级

certified by the Biological Stain Commission

形式

powder

组成

Dye content, ≥82%

应用

hematology: suitable
histology: suitable

溶解性

H2O: 4mg/4ml

特色行业

Diagnostic Assay Manufacturing

储存温度

room temp

SMILES string

CN(C)C1=CC=C2C(SC(C3=N2)=CC(C=C3)=[N+](C)C)=C1.[H]O[H].[Cl-]

InChI

1S/C16H18N3S.ClH.H2O/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10H,1-4H3;1H;1H2/q+1;;/p-1

InChI key

WQVSELLRAGBDLX-UHFFFAOYSA-M

Gene Information

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一般描述

亚甲蓝是晶体或结晶粉末形式的化合物,具有类似青铜的光泽。这种成分可溶于水和氯仿,部分溶于乙醇。它是一种光敏染料,属于吩噻嗪家族成员。

应用

亚甲蓝已用于:
  • 对阴道细胞染色
  • 制备蛋白质水性墨水
  • 染色评估细胞存活率

包装

25, 100 g in glass bottle

生化/生理作用

亚甲蓝可用作细菌学染色剂或染料和指示剂。在可见光下,它会介导血浆中的包膜病毒失活。这种成分是一氧化氮合酶和鸟苷酸环化酶抑制剂。它在医学上也具有重要作用,可用作抗疟药、高铁血红蛋白血症还原剂和癌细胞凋亡诱导剂。

适用性

经认证可用于Mallory&# 8242;s二氢四溴萤光素-亚甲基蓝染色;牛奶中细菌的Levine &黑色染色;血液涂片的Wright染色。

象形图

Exclamation mark

警示用语:

Warning

危险声明

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

原产地证书 (CofO)

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Methylene blue, Product M9140?

    The product is soluble in water at 50 mg/mL, EGME at 60 mg/mL and ethanol at 70 mg/mL. EGME is an abbreviation for ethylene glycol monomethyl ether, also known as 2-methoxyethanol or methyl cellosolve.

  4. How can Methylene blue, Product M9140, be used?

    Probably its most important application is as an in vitro diagnostic bacteriology, cytology, hematology, and histology stain. Methylene Blue serves as a precursor to the Methylene Azures and as a component of the various Ramanowsky-type blood stains (Wright, Leishman, Giemsa and others). While pure Methylene Blue is not a good nuclear stain, it readily undergoes oxidative demethylation to form the various Methylene Azures, which are good nuclear stains.

  5. How is dye content determined for Methylene blue, Product M9140?

    Dye content is determined spectrophotometrically by noting the dye's absorbance peak, which is typically near 665 nm, or by calculating the ratio of the absorbances at 650 nm over 680 nm. (The dye exhibits smaller peaks at approximately 292 and 246 nm).

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Petrov VM and Karam JD
Nucleic Acids Research, 30, 3341-3341 (2002)
Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects (2008)
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
Xiao GY
PLoS ONE, 9, e106538-e106538 (2014)
DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline
Trudler D, et al.
Journal of Neurochemistry, 129(3) (2014)
Methylene blue: revisited
Ginimuge PR and Jyothi SD
Journal of Anaesthesiology, Clinical Pharmacology, 26(4), 517-517 (2010)

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