PE5000

Dimethyl Sulfone - qNMR

proficiency testing material

Properties

• 质量水平: 100
• 形式: solid
• 包装: pack of 1 × 100 mg
• application(s): pharmaceutical

Description

一般描述

Dimethyl Sulfone - qNMR proficiency testing material is produced in accordance with ISO/IEC 17043:2010. The PT portfolio allows our test components to offer significant performance data to monitor and prove competency to customers, accreditation bodies or both.

Supelco^® Pharmaceutical Proficiency Testing scheme is mainly designed to meet the needs of the pharmaceutical industry.
The pharma PT samples allow laboratories to demonstrate their competence in following compendial USP methods of analysis. They can be used to assure accreditors or auditors that the lab processes are followed accordingly. Our pharmaceutical PT scheme covers products under categories such as Chemical Tests and Assays, Physical Tests and Determinations and Microbiological Tests.

Type of PT Scheme: Pharmaceuticals

All information regarding the use of Dimethyl Sulfone - qNMR proficiency testing standard can be found in the reporting packet which will be available to download at PT Portal.

应用

Testing consists of determination of the content via Quantitative NMR Spectroscopy. Content is in the range of min. 90%.

Dimethyl Sulfone - qNMR proficiency testing material is used for the analysis of dimethyl sulfone compound in pharmaceutical industry using qNMR technique.

Have any questions? Explore our FAQs.
For more information on this product, please contact our PT Service Team.

特点和优势

We have a vast portfolio of environmental PT schemes with "fit-for-purpose" samples to help you meet the needs of the laboratory.

Our proficiency testing (PT) program is a benchmark to:

• provide staff with an insight into their laboratory′s performance, to verify the accuracy and reliability of their testing process
• provide a comparison of performance with that of other laboratories, nationally and internationally
• test and educate staff, provide a better understanding of the impact of incorrect results and identify areas where there may be problems
• provide an independent evaluation of laboratory performance
• demonstrate to clients, colleagues and accreditation bodies that there is a commitment to quality

制备说明

Description

• The sample contains Dimethylsulfone (C₂H₆O₂S, molecular mass 94.13 g/mol) as the main component. The purity value of Dimethylsulfone is determined by quantitative ¹H NMR (Nuclear Magnetic Resonance).
• Each unit PE5000 consists of 100 mg white powder.
• As solvent, deuterated oxide (D₂O) should be used (not delivered).
• As internal (or external) standard, the CRM maleic acid (Sigma-Aldrich qNMR CRM 92816) should be used (not delivered).
• The sample must be stored at 4 °C.
• The number of samples analyzed and the number of repetitions per sample are defined by the user.

Sample Preparation

• The sample needs no special treatment before use.
• Use your standard sample preparation procedure.
• Weigh the internal standard maleic acid and PE5000 using an appropriate balance (e.g., microbalance, ultra-microbalance). Use a ratio of sample and internal standard according to your standard procedure using minimum weights of 10 mg for sample PE5000 and maleic acid.
• Dissolve both compounds in deuterated oxide (D₂O). Both compounds should be dissolved completely.
• Transfer the solution to an NMR tube and carefully attach a cap.
• Perform NMR analysis immediately after dissolving.

qNMR measurement

• Use your standard qNMR parameters for measurements.
• T1 time for Maleic acid in D₂O is 6 seconds (10 mg/mL neat material, measured on a 600 MHz Prodigy NMR spectrometer), T₁ time for Dimethylsulfone in D₂O is 3 seconds (10 mg/mL neat material, measured on a 600 MHz Prodigy NMR spectrometer).
• Be aware that T₁ relaxation times can change with concentration, solvent used and NMR spectrometer.
• We recommend a relaxation delay ≥7 times longest T₁ time.

Analysis

• Data Processing and Integration: Use your standard processing procedure for qNMR measurements.
• The results should be reported as %, calculated from mass fraction g/g. (e.g. 95.50 % Dimethylsulfone) in the Proficiency Testing Portal.

Item Analyte Ranges

Dimethylsulfone: 90.00-100.00% (g/g)

储存及稳定性

Please refer to sample label for expiration date, specific storage temperature and specific storage conditions.

分析说明

For content determination via qNMR, an internal standard and a deuterated solvent are necessary. Recommended product: 92816-1G Maleic Acid; recommended solvent: D₂O

其他说明

Are you new to Supelco^® Proficiency Testing? Be sure to register your account details in the PT Portal before placing your order.
This will provide access to data entry, reporting packets and final reports. Registrations will be approved shortly after your order is placed. For further questions, write to us at ptservice@milliporesigma.com.

When placing your order online, please indicate your study preference under the ′your reference′ column. Available studies can be viewed at the bottom of the page.
Click here to learn more about Quick-Turn Studies (on-demand proficiency tests that are offered depending on lot availability). The Quick-Turn results are released within 48-72 hours whereas scheduled study reports are released within 21 days.

Proficiency Testing Schedule 2021
Quick-Turn Study - (non-scheduled proficiency test that is available at any time)

法律信息

Supelco is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable