所有图片(1)

PHR1008

Supelco

维生素C

Pharmaceutical Secondary Standard; Certified Reference Material

别名:
维生素 C, 抗坏血病因子, L -抗坏血酸, L-维生素 C
Empirical Formula (Hill Notation):
C6H8O6
CAS号:
分子量:
176.12
Beilstein:
84272
EC 号:
MDL编号:
PubChem化学物质编号:
E编号:
E300
NACRES:
NA.24

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

形式

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

190-194 °C (dec.)

application(s)

food and beverages

格式

neat

药典可追溯性

traceable to BP 461
traceable to PhEur A1300000
traceable to USP 1043003

储存温度

2-8°C

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

正在寻找类似产品? Visit 产品对比指南

一般描述

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。抗坏血酸是一种强大的抗氧化剂,广泛用于药物制剂中。经证其对衰老相关疾病(如癌症、动脉粥样硬化、眼病、神经退行性疾病等)具有有益作用。它主要参与胶原蛋白的形成和维持。饮食长期缺乏抗坏血酸会导致坏血病。

应用

抗坏血酸可用制药参考标准品,通过亲水作用色谱定量药物制剂中的分析物。

生化/生理作用

抗坏血酸,也称为维生素C,是由植物和一些动物物种(不包括人类和其他灵长类动物)产生的六碳内酯。抗坏血酸可作为多种酶的酶促辅助因子,可用作单加氧酶和双加氧酶的电子供体。抗坏血酸还起到强力抗氧化剂的作用,特别是对活性氧。

分析说明

这些二级标准品为USP、EP(PhEur)和BP等主要标准品提供了多种可追溯性。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

想要查看本品的分析证书示例,请在下框中输入LRAC2886。这只是一个示例证书,可能与您收到的批次不符。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

L-ascorbic acid determination in pharmaceutical formulations using a biosensor based on carbon paste modified with crude extract of Zucchini (Cucurbita pepo)
Fatibello-Filho and Vieira CI
Journal of the Brazilian Chemical Society, 11(4), 412-418 (2000)
Simultaneous differential pulse voltammetric determination of ascorbic acid and caffeine in pharmaceutical formulations using a boron?doped diamond electrode
Lourencao CB, et al.
Electroanalysis, 22(15), 1717-1723 (2010)
Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology
Hatambeygi N, et al.
Journal of Chromatography A, 1218(35), 5995-6003 (2011)
Marc P Bradshaw et al.
Critical reviews in food science and nutrition, 51(6), 479-498 (2011-09-21)
Extensive reviews of research are available on the use of ascorbic acid, and its consequent degradation pathways, in physiological conditions or food matrices. However, very little information can be found for wine-related systems. This review highlights the relevant chemistry and
Noriko Umegaki-Arao et al.
Science translational medicine, 6(264), 264ra164-264ra164 (2014-11-28)
Revertant mosaicism is a naturally occurring phenomenon involving spontaneous correction of a pathogenic gene mutation in a somatic cell. It has been observed in several genetic diseases, including epidermolysis bullosa (EB), a group of inherited skin disorders characterized by blistering

实验方案

HPLC Analysis of Ascorbic Acid on Ascentis® RP-Amide

Separation of (L)-Dehydroascorbic acid; L-Ascorbic acid 20 μg/mL

HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

Separation of Pyridoxine; Nicotinamide; Nicotinic acid; Folic acid; (−)-Riboflavin, meets USP testing specifications; L-Ascorbic acid

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门