PHR1009

咖啡因

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 1,3,7-三甲基黄嘌呤
• Empirical Formula (Hill Notation): C₈H₁₀N₄O₂
• CAS Number: 58-08-2
• Molecular Weight: 194.19
• Beilstein: 17705
• MDL编号: MFCD00005758
• PubChem化学物质编号: 329823040
• NACRES: NA.24

Properties

• 等级: certified reference material; pharmaceutical secondary standard
• 质量水平: 300
• Agency: traceable to BP 766; traceable to Ph. Eur. C0100000; traceable to USP 1085003
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 234-236.5 °C (lit.)
• application(s): pharmaceutical (small molecule)
• 格式: neat
• 储存温度: 2-30°C
• SMILES string: CN1C(=O)N(C)c2ncn(C)c2C1=O
• InChI: 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
• InChI key: RYYVLZVUVIJVGH-UHFFFAOYSA-N
• Gene Information: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Description

一般描述

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.

应用

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

中枢神经系统兴奋剂，被认为通过腺苷受体和单胺类神经递质发挥作用。 可作为腺苷受体拮抗剂和腺苷3′,5′-环单磷酸(cAMP)磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内cAMP的水平将升高。据报道，它会影响细胞钙水平，使细胞内的钙离子外流。它会使多种化学物质（例如蛋白酶抑制剂）的细胞周期效应无效，从而防止细胞凋亡；同时，还发现它可以抑制细胞的DNA修复机制。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302
• 预防措施声明: P264 - P270 - P301 + P312 - P501
• 危险分类: Acute Tox. 4 Oral
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1