所有图片(1)

PHR1035

Supelco

叶酸

Pharmaceutical Secondary Standard; Certified Reference Material

别名:
N- [4 -[[(2-氨基-1,4-二氢-4-氧代-6-哌啶基)甲基]氨基]苯甲酰基] -L-谷氨酸, N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M
Empirical Formula (Hill Notation):
C19H19N7O6
CAS号:
分子量:
441.40
Beilstein:
100781
EC 号:
MDL编号:
eCl@ss:
34058014
PubChem化学物质编号:
NACRES:
NA.24

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

药典可追溯性

traceable to PhEur F0300000
traceable to USP 1286005

储存温度

2-30°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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一般描述

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
叶酸主要来源于膳食本身,也可从维生素药片等药品中获取。†服用叶酸对于预防神经管缺陷(主要为无脑畸形和脊柱裂)十分必要。†它属于水溶性维生素B族成员。主要用于强化杂粮/谷物和膳食补充剂。

应用

叶酸可作为药物参考标准品,用于通过紫外分光光度技术和微乳电动毛细管色谱对药物制剂中的分析物进行定量。
这些二级标准品是经认证过的有证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

要查看该材料的分析证书示例,请在下面的栏位中输入LRAB7352。这只是一个示例证书,可能不是您收到的批次。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

分析证书

原产地证书 (CofO)

更多文件

Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chromatography/tandem mass spectrometry
Nelson.CB, et al.
Journal of Chromatography A, 1135, 203-211 (2006)
Determination of folic acid in tablets by microemulsion electrokinetic chromatography
Aurora-Prado SM, et al.
Journal of Chromatography A, 1051(1-2), 291-296 (2004)
A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests
Matias R, et al.
Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)
Vinod Devalia et al.
British journal of haematology, 166(4), 496-513 (2014-06-20)
The clinical picture is the most important factor in assessing the significance of test results assessing cobalamin status because there is no 'gold standard' test to define deficiency. Serum cobalamin currently remains the first-line test, with additional second-line plasma methylmalonic
Andrew J Copp et al.
The Lancet. Neurology, 12(8), 799-810 (2013-06-25)
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary

技术文章

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18

Pyridoxine hydrochloride, ≥98% (HPLC); Nicotinamide, ≥98.5% (HPLC); Thiamine hydrochloride, reagent grade, ≥99% (HPLC); Biotin, ≥99.0% (T); Folic acid, analytical standard; Cyanocobalamin (B12), analytical standard; Riboflavin (B2), analytical standard

实验方案

HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

Separation of Pyridoxine; Nicotinamide; Nicotinic acid; Folic acid; (−)-Riboflavin, meets USP testing specifications; L-Ascorbic acid

相关内容

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18

Pyridoxine hydrochloride, ≥98% (HPLC); Nicotinamide, ≥98.5% (HPLC); Thiamine hydrochloride, reagent grade, ≥99% (HPLC); Biotin, ≥99.0% (T); Folic acid, analytical standard; Cyanocobalamin (B12), analytical standard; Riboflavin (B2), analytical standard

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