Merck
所有图片(1)

PHR1237

Supelco

胆钙化醇

Pharmaceutical Secondary Standard; Certified Reference Material

别名:
胆钙化醇, 活化7-脱氢胆固醇, (+)-维生素 D3, 胆骨化醇, 活化7-脱氢胆甾醇
Empirical Formula (Hill Notation):
C27H44O
CAS号:
分子量:
384.64
Beilstein:
2339331
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

Agency

traceable to BP 787
traceable to Ph. Eur. C2100000
traceable to USP 1131009

形式

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

83-86 °C (lit.)

application(s)

food and beverages

格式

neat

储存温度

-10 to -25°C

SMILES string

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Gene Information

human ... VDR(7421)

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一般描述

用于质量控制的制药二级标准品为制药实验室和制造商内部制备工作标准品提供了一种方便、高性价比的替代方案。
胆钙化醇(维生素D3)是一种脂溶性维生素,能体现对骨骼和骨骼外效应。骨骼效应增强骨骼健康,而骨骼外效应则涉及免疫系统、认知系统、心血管系统等。

应用

胆钙化醇(维生素D3)可作为制药参考标准品,通过各种色谱技术测定食品、种子、血清样本和制药制剂中的分析物。
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。

生化/生理作用

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。

分析说明

这些二级标准品为USP、EP(PhEur)和BP等主要标准品提供了多种可追溯性。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

欲查看此物质的分析证书样本,请在下面的对话框中输入LRAC0270。其仅是一个示例证书,可能不是您所收到的批次。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

请输入批号搜索分析证书(COA)。

原产地证书 (CofO)

请输入批号搜索原产地证书(COO)。

更多文件

Quotes and Ordering

High-performance liquid chromatographic determination of vitamin D in foods, feeds and pharmaceuticals by successive use of reversed-phase and straight-phase columns
TAKEUCHI A, et al.
Journal of nutritional science and vitaminology, 30(1), 11-25 (1984)
Is supercritical fluid chromatography hyphenated to mass spectrometry suitable for the quality control of vitamin D3 oily formulations?
Andri B, et al.
Journal of Chromatography A, 1515(5-6), 209-217 (2017)
Simultaneous microemulsion liquid chromatographic analysis of fat-soluble vitamins in pharmaceutical formulations: optimization using genetic algorithm
Momenbeik F, et al.
Journal of Chromatography A, 1217(24), 3770-3773 (2010)
Determination of vitamins A, D, E, and K in human and bovine serum, and ?-carotene and vitamin A palmitate in cosmetic and pharmaceutical products, by isocratic HPLC
Wang LH and Huang SH
Chromatographia, 55(5-6), 289-296 (2002)
Sara S Oberhelman et al.
Mayo Clinic proceedings, 88(12), 1378-1387 (2013-12-03)
To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Forty mothers with exclusively breast-fed infants were randomized to receive oral

实验方案

AOAC Method 2011.11: UHPLC/MS/MS Analysis of Vitamin D2 and Vitamin D3 on Titan™ C18

Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

HPLC Analysis of Vitamin D2 and D3 on Ascentis® Express C18

This application demonstrates the suitability of the Ascentis Express C18, 5 μm, for the routine analysis of the fat-soluble vitamins D2 and D3 . Structures along with the optimized chromatogram obtained on the Ascentis Express C18, 5 μm are presented.

HPLC Analysis of Vitamin D2 and Vitamin D3 on Ascentis® C18

Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

查看所有结果

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