Merck
All Photos(1)

PHR1251

Supelco

氯化胆碱

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
(2-羟乙基)三甲基氯化铵
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
Beilstein:
3563126
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1133547

API family

choline chloride

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

302-305 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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This Item
W450001C75271133547
Choline chloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1251

氯化胆碱

Choline chloride FCC

Sigma-Aldrich

W450001

氯化胆碱

Choline chloride BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sigma-Aldrich

C7527

氯化胆碱

Choline chloride United States Pharmacopeia (USP) Reference Standard

USP

1133547

氯化胆碱

grade

certified reference material, pharmaceutical secondary standard

grade

Halal, Kosher

grade

-

grade

pharmaceutical primary standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

flavors and fragrances

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

-

format

neat

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

300

Quality Level

400

Quality Level

300

Quality Level

-

一般描述

用于质量控制的制药二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

应用

氯化胆碱可用作药物参考标准品,用于通过液相色谱技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

丁酰胆碱酯酶(BChE)和对氧磷酯酶1(PON1)是由肝脏合成的并且与炎症相关的血清酶,这两种酶在注射LPS的脓毒症动物模型中的活性降低。氯化胆碱以20mg/kg体重的剂量静脉注射给药,可防止LPS介导的BChE和PON1酶活性降低 。

底物

胆碱乙酰基转移酶底物

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

本有证标准物质 (CRM) 按照 ISO 17034 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息,请参见检验报告。

附注

欲查看此物质的分析证书示例,请在下框中输入LRAC3558。这只是一个示例证书,可能与您收到的批次不符。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable


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