所有图片(1)

PHR1379

Supelco

硫酸阿托品

Pharmaceutical Secondary Standard; Certified Reference Material

别名:
龙葵碱, (8-甲基-8-氮杂双环[3.2.1]辛-3-基) edno-(+/-)-α-(羟甲基)苯乙酸酯, 阿托品 硫酸盐 一水合物
线性分子式:
(C17H23NO3)2 · H2SO4 · H2O
CAS号:
分子量:
694.83
Beilstein:
6109275
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

形式

neat

CofA

current certificate can be downloaded

应用

HPLC: suitable
gas chromatography (GC): suitable

mp

189-192 °C (A) (lit.)

特色行业

Pharmaceutical (small molecule)

格式

neat

药典可追溯性

traceable to BP 23
traceable to PhEur A1400000
traceable to USP 1045009

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

Gene Information

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Atropine Sulfate is an alkaloid extracted from belladonna herb. It is a cholinergic drug, administered as an anti-arrhythmic medicine.

应用

Atropine Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrophoresis and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

附注

To see an example of a Certificate of Analysis for this material enter LRAC4087 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Determination of atropine sulfate using a novel sensitive DNA-biosensor based on its interaction on a modified pencil graphite electrode.
Ensafi AA, et al.
Talanta, 131, 149-155 (2015)
Development and validation of a capillary zone electrophoresis method for the determination of atropine, homatropine and scopolamine in ophthalmic solutions.
Cherkaoui S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 696(2), 283-290 (1997)
Determination of atropine in pharmaceutical preparations by liquid chromatography with fluorescence detection.
Takahashi M, et al.
Journal of Chromatography A, 775(1-2), 137-141 (1997)
LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.
Ceyhan T, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(3-4), 399-406 (2001)
Cristina Cuesta et al.
Vascular pharmacology, 63(1), 4-12 (2014-09-03)
The role of calcitonin gene-related peptide (CGRP) in the modulation of vascular tone has been widely documented. Indeed, electrical stimulation of the perivascular sensory outflow in pithed rats induces vasodepressor responses by activation of CGRP receptors. This study investigated the...

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