所有图片(1)

T176

Supelco

4-羟基他莫西芬

analytical standard, (E) and (Z) isomers (50:50)

别名:
顺/反-4-羟基三苯氧胺, 4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚, 4-OHT
Empirical Formula (Hill Notation):
C26H29NO2
CAS号:
分子量:
387.51
PubChem化学物质编号:
NACRES:
NA.24

质量水平

200

等级

analytical standard

形式

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

溶解性

ethanol: 20 mg/mL

抗生素抗菌谱

neoplastics

application(s)

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

作用机制

enzyme | inhibits

SMILES string

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6

InChI

1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-

InChI key

ZJLDABGSDWXVGE-BDSXMVAQSA-N

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应用

有关合适仪器技术的更多信息,请参考产品 分析证书。如需进一步支持,请联系技术服务。

包装

10, 50 mg in poly bottle

生化/生理作用

化疗药物他莫西芬的代谢物,表现出比原药更强效的雌激素激动剂/拮抗剂活性。还是脂质过氧化的活性膜内抑制剂。

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

分析证书

原产地证书 (CofO)

Takashi K Ito et al.
PloS one, 9(7), e102186-e102186 (2014-07-25)
Risk factors for atherosclerosis accelerate the senescence of vascular endothelial cells and promote atherogenesis by inducing vascular inflammation. A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic inflammation
Michael J Chisamore et al.
PloS one, 4(5), e5624-e5624 (2009-05-23)
The orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) is a member of the nuclear receptor superfamily. It was identified through a search for genes encoding proteins related to estrogen receptor alpha (ERalpha). An endogenous ligand has not been found. Novel
Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain.
Brossas, et al.
The Embo Journal, 39, e99520-e99520 (2021)
Olga S Koutsopoulos et al.
PloS one, 6(11), e27498-e27498 (2011-11-19)
The large GTPase dynamin 2 is a key player in membrane and cytoskeletal dynamics mutated in centronuclear myopathy (CNM) and Charcot-Marie Tooth (CMT) neuropathy, two discrete dominant neuromuscular disorders affecting skeletal muscle and peripheral nerves respectively. The molecular basis for
Paolo Cinelli et al.
BMC developmental biology, 8, 57-57 (2008-05-27)
The transcription factor STAT3 is a downstream target of the LIF signalling cascade. LIF signalling or activation is sufficient to maintain embryonic stem (ES) cells in an undifferentiated and pluripotent state. To further investigate the importance of STAT3 in the

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