Merck

107M-2

Sigma-Aldrich

CD7 (MRQ-56) Mouse Monoclonal Antibody

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NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

culture supernatant

antibody product type

primary antibodies

克隆

MRQ-56, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形式

buffered aqueous solution

species reactivity

human

包装

vial of 0.1 mL concentrate (107M-24)
vial of 0.5 mL concentrate (107M-25)
bottle of 1.0 mL predilute (107M-27)
vial of 1.0 mL concentrate (107M-26)
bottle of 7.0 mL predilute (107M-28)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同位素/亚型

IgG1

控制

lymph node, peripheral T-cell lymphoma, tonsil

运输

wet ice

储存温度

2-8°C

可视化

membranous

Gene Information

human ... CD7(924)

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107R-1123M-2205R-2
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

MRQ-56, monoclonal

clone

EP132, monoclonal

clone

MRQ-57, monoclonal

clone

EP77, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

一般描述

CD7 antigen is a cell surface glycoprotein of 40 kD expressed on the surface of immature and mature T-cells as well as natural Killer (NK) cells. It is a member of the immunoglobulin gene superfamily and is the first T-cell lineage associated antigen to appear in T-cell ontogeny, being expressed in T-cell precursors (preceding CD2 expression), and in myeloid precursors, in fetal liver and bone marrow, and persisting in circulating mature T-cells. While its precise function is not known, it is suggested that the molecule functions as an Fc receptor for IgM. CD7 is the most consistently expressed T-cell antigen in lymphoblastic lymphomas/leukemias, and is therefore anti-CD7 is a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T-cell neoplasms, CD7 is the most common pan-T-antigen to be aberrantly expressed, which is a useful pointer to a neoplastic T-cell process. CD7 has been shown to be immunoexpressed in 85% of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, T-cell lymphoblastic leukemia/lymphoma, acute myeloid leukemia, and chronic myelogenous leukemia, CD7 is conspicuously absent in adult T-cell leukemia/lymphoma and is not expressed in mycosis fungoides.

质量


IVD

IVD

IVD

RUO

联系

CD7 Positive Control Slides, Product No. 107S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(F)

Not applicable

闪点(C)

Not applicable


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Philip Went et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(16), 2472-2479 (2006-04-26)
Although peripheral T-cell lymphoma, unspecified (PTCL/U), is the most common T-cell tumor in Western countries, no study to date has been based on the application of a wide panel of markers to a large series of patients and assessed the
Eric C Vonderheid
Journal of cutaneous pathology, 33 Suppl 1, 27-42 (2006-01-18)
Erythrodermic cutaneous T-cell lymphoma (E-CTCL) is the cause of less than 5% of all cases of generalized erythroderma. A methodical evaluation of skin, blood, and lymph node samples using standard histology, immunohistochemistry (IHC), flow cytometry (FC), and molecular analysis for
Emmilia Hodak et al.
Journal of the American Academy of Dermatology, 55(2), 276-284 (2006-07-18)
Mycosis fungoides (MF) is an epidermotropic cutaneous T-cell lymphoma in which the tumor cells express a mature T-helper memory phenotype, ie, CD3(+), CD4(+), CD8(-), CD45RO(+), with a T-cell receptor (TCR) of the alpha/beta heterodimer. A minority of patients have an

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