Merck
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文件

17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

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别名:
O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate
线性分子式:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS号:
31961-02-1
MDL编号:
MFCD00284260
NACRES:
NA.26

形式

powder

质量水平

100

分子量

Mr ~2100

mp

50-53 °C

Ω端

carboxylic acid

α端

methoxy

储存温度

−20°C

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此商品
1792973261370718
O-Methyl-O′-succinylpolyethylene glycol 2′000

Sigma-Aldrich

17928

O-Methyl-O′-succinylpolyethylene glycol 2′000

O-Methyl-O′-succinylpolyethylene glycol 5′000

Sigma-Aldrich

17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

Poly(ethylene glycol) methyl ether average Mn 20,000

Sigma-Aldrich

732613

聚乙二醇甲基醚

Methoxypolyethylene glycol 5,000 acetic acid ≥80%

Sigma-Aldrich

70718

Methoxypolyethylene glycol 5,000 acetic acid

mol wt

Mr ~2100

mol wt

Mr ~5100

mol wt

average Mn 20,000

mol wt

-

mp

50-53 °C

mp

56-60 °C

mp

64-69 °C

mp

-

Ω-end

carboxylic acid

Ω-end

carboxylic acid

Ω-end

hydroxyl

Ω-end

carboxylic acid

α-end

methoxy

α-end

methoxy

α-end

methoxy

α-end

methoxy

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

应用

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

生化/生理作用

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Poly(ethylene glycol) bis(carboxymethyl) ether average Mn 600

Sigma-Aldrich

407038

聚乙二醇二羧酸

O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol 2′000

Sigma-Aldrich

41214

O-[(N-琥珀酰亚胺基)琥珀酰氨基乙基]-O′-甲基聚乙二醇 2′000

mPEG10K-Succinimidyl Carboxymethyl Ester average Mn 10,000

Sigma-Aldrich

JKA3016

mPEG10K-Succinimidyl Carboxymethyl Ester

4-Azidobenzoic acid solution ~0.2 M in tert-butyl methyl ether, ≥95.0% (HPLC)

Sigma-Aldrich

778877

4-叠氮苯甲酸 溶液

Poly(ethylene glycol) methyl ether average Mn ~2,000

Sigma-Aldrich

202509

聚乙二醇甲基醚

Polyethylene glycol 2000, for synthesis

Sigma-Aldrich

8.21037

聚乙二醇2000

DCC 99%

Sigma-Aldrich

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N,N′-二环己基碳二亚胺

Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [(3)H]-hypoxanthine in the nucleic acid of parasites. Stearylamine in liposomes significantly inhibits the growth of
Ayman El-Sayed et al.
Journal of pharmaceutical sciences, 101(2), 879-882 (2011-11-17)
We previously reported on a stearylated INF7 peptide (str-INF7), which enhances the endosomal escape of an octaarginine (R8)-modified liposomal particle encapsulating plasmid DNA (pDNA) in a fusion-independent manner. This study examined whether this peptide derivative enhanced the endosomal escape and
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
M Z Atassi et al.
Journal of protein chemistry, 10(6), 623-627 (1991-12-01)
Recent studies from this laboratory showed that tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens. This paper describes the procedure for synthesis of well-defined conjugates of
Peter M Fischer et al.
Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid-phase chemistries and combines the inherent advantages of both approaches. The technical simplicity and scalability of the liquid-phase peptide synthesis method renders
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