Merck

26978

Sigma-Aldrich

氯化胆碱

BioUltra, ≥99.0% (AT)

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别名:
(2-羟乙基)三甲基氯化铵
线性分子式:
(CH3)3N(Cl)CH2CH2OH
CAS号:
分子量:
139.62
Beilstein:
3563126
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

生物来源

synthetic

产品线

BioUltra

检测方案

≥99.0% (AT)

形式

powder or crystals

杂质

insoluble matter, passes filter test

颜色

colorless to white

pH值(酸碱度)

5.0-7.5 (25 °C, 1 M in H2O)

mp

302-305 °C (dec.) (lit.)

溶解性

H2O: 1 M, clear, colorless

痕量阴离子

sulfate (SO42-): ≤50 mg/kg

痕量阳离子

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

紫外吸收

λ: 260 nm Amax: 0.015
λ: 280 nm Amax: 0.010

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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此商品
C7017W450001PHG0021
Choline chloride BioUltra, ≥99.0% (AT)

Sigma-Aldrich

26978

氯化胆碱

Premium Grade
Choline chloride ≥99%

Sigma-Aldrich

C7017

氯化胆碱

-
Choline chloride FCC

Sigma-Aldrich

W450001

氯化胆碱

-
Choline chloride

SAFC

PHG0021

氯化胆碱

-
form

powder or crystals

form

powder

form

powder, crystals or chunks

form

powder

impurities

insoluble matter, passes filter test

impurities

-

impurities

-

impurities

Endotoxin, microbial and lead, tested

pH

5.0-7.5 (25 °C, 1 M in H2O)

pH

-

pH

-

pH

5.0-6.5 (25 °C, 140 g/L)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

mp

302-305 °C (dec.) (lit.)

solubility

H2O: 1 M, clear, colorless

solubility

-

solubility

-

solubility

water: soluble 140 g/L

生化/生理作用

丁酰胆碱酯酶(BChE)和对氧磷酯酶1(PON1)是由肝脏合成的并且与炎症相关的血清酶,这两种酶在注射LPS的脓毒症动物模型中的活性降低。氯化胆碱以20mg/kg体重的剂量静脉注射给药,可防止LPS介导的BChE和PON1酶活性降低 。
胆碱是一种必需营养素,通常与B族复合维生素组合,在许多生物过程中发挥关键作用。

底物

胆碱乙酰基转移酶底物

其他说明

恢复剥除皮质大鼠的纹状体的胆碱能、生化和药理活性
销售限制可能适用

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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货号
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氢氧化胆碱 溶液

S Consolo et al.
Journal of neurochemistry, 54(2), 571-577 (1990-02-01)
Interruption of the corticostriatal pathway by undercutting the frontal cortex resulted after 2 weeks in a 40% reduction of basal acetylcholine (ACh) release in vivo, and in inhibition of the striatal sodium-dependent high-affinity uptake of choline (SDHACU) to the same
Mohsen Beheshti et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 833-840 (2013-04-06)
We evaluated the potential of (18)F-fluoromethyldimethyl-2-hydroxyethyl-ammonium (FCH) PET/CT in the detection of recurrent disease or distant metastases and correlated its diagnostic accuracy with prostate-specific antigen (PSA) levels in prostate cancer patients with biochemical evidence of recurrence. Furthermore, the influences of
Elisabeth Traiffort et al.
Molecular aspects of medicine, 34(2-3), 646-654 (2013-03-20)
The Na(+)-independent, high affinity choline carrier system proposed to supply choline for the synthesis of cell membrane phospholipids was recently associated with SLC44 family members (SLC44A1-5) also called choline-like transporter family. SLC44A1 is widely expressed throughout the nervous system in
Sotirios Chondrogiannis et al.
European journal of nuclear medicine and molecular imaging, 40(9), 1356-1364 (2013-05-15)
The aims of the study were (a) to evaluate the diagnostic role, by means of positive detection rate (PDR), of ¹⁸F-choline (CH) positron emission tomography (PET)/CT in patients with prostate cancer treated with radiotherapy, with curative intent, and suspicion of
Zhuo Li et al.
Biochimica et biophysica acta, 1840(7), 2112-2122 (2014-03-19)
Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb(-/-) mice display neonatal forelimb bone deformations. To understand the mechanisms underlying the bone deformations, we compared the

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