Merck

328R-1

Sigma-Aldrich

PU.1 (EPR3158Y) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

culture supernatant

antibody product type

primary antibodies

克隆

EPR3158Y, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形式

buffered aqueous solution

species reactivity

human

包装

vial of 0.1 mL concentrate (328R-14)
vial of 0.5 mL concentrate (328R-15)
bottle of 1.0 mL predilute (328R-17)
vial of 1.0 mL concentrate (328R-16)
bottle of 7.0 mL predilute (328R-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

同位素/亚型

IgG

控制

tonsil

运输

wet ice

储存温度

2-8°C

可视化

nuclear

Gene Information

human ... SPI1(6688)

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SAB5500170312R-2294R-1
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

affinity isolated antibody

antibody form

culture supernatant

antibody form

culture supernatant

clone

EPR3158Y, monoclonal

clone

SP238, monoclonal

clone

EP156, monoclonal

clone

SP92, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human (tested)

species reactivity

human

species reactivity

human

一般描述

PU.1 is a transcription factor that has been shown to be important for normal B-cell development. PU.1 belongs to the ETS family of transcription factors. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. Very little is known about PU.1 function in later stages of B-cell development. PU.1 does not seem to play a role in the end-stage of B-cell development and is not expressed in plasma cells. PU.1 exerts an important role in the regulation of the expression of crucial B-cell proteins, such as immunoglobulin (Ig) genes, and CD20 and its putative binding sites were also identified in the promoters of CD79, CD10, and CD22. PU.1 binds to the 3′ enhancer region of both the Ig kappa and lambda light chain genes and it also regulates the immunoglobulin heavy chain genes through the intron enhancer region. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, and nodular lymphocyte predominant Hodgkin lymphoma.

质量


IVD

IVD

IVD

RUO

联系

PU.1 Positive Control Slides, Product No. 328S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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T1503
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25G
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R Hromas et al.
Blood, 82(10), 2998-3004 (1993-11-15)
The ETS oncogene family member PU.1 is a transcriptional activator that is dysregulated by Friend erythroleukemia virus insertion. Northern analysis found that PU.1 is highly expressed in cells of myeloid and B-lymphoid origin, but not expressed at all in a
Juliette J Hoefnagel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(9), 1270-1276 (2006-06-17)
Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with expression patterns during normal B-cell development. The following transcription factors were investigated: Pax-5
Christoph Loddenkemper et al.
The Journal of pathology, 202(1), 60-69 (2003-12-25)
It has previously been demonstrated that in cultured and in situ tumour cells of classical Hodgkin lymphoma (cHL), the immunoglobulin (Ig) promoter is inactive and its transcription factors Oct2 and/or BOB.1/OBF.1 are down-regulated. In this study, the analysis of these

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