Merck

356M-1

Sigma-Aldrich

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

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NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

culture supernatant

antibody product type

primary antibodies

克隆

D5 & 16B4, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形式

buffered aqueous solution

species reactivity

human

包装

vial of 0.1 mL concentrate (356M-14)
vial of 0.5 mL concentrate (356M-15)
bottle of 1.0 mL predilute (356M-17)
vial of 1.0 mL concentrate (356M-16)
bottle of 7.0 mL predilute (356M-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

同位素/亚型

IgG1

控制

mesothelioma

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

Gene Information

human ... KRT5(3852)

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902H-0356R-1905H-0
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

purified immunoglobulin

clone

D5 & 16B4, monoclonal

clone

D5&16B4 + 8G7G3/1, monoclonal

clone

EP24 & EP67, monoclonal

clone

EP1601Y + LL002, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

一般描述

Anti-CK 5 & 6 positivity is seen in 65% to 100% of epithelioid mesotheliomas, in 0% to 19% of lung adenocarcinomas, and in 22% to 80% of serous carcinoma of the ovary and peritoneum. Keratin 5 & 6 expression in lung adenocarcinoma is not common, and when it occurs, the reaction is usually confined to small focal areas or scattered cells. The most probable cause of this finding is the presence of squamous differentiation of lung adenocarcinoma. Anti-CK 5 & 6 positivity has been useful in recognizing squamous cell carcinoma of the skin. Less than 10% of carcinomas of the breast, colon, and prostate stain positively for this marker. Anti-CK 5 & 6 has also been used successfully as a myoepithelial cell marker in the prostate and breast to determine malignancy. Anti-CK 5 & 6 is a useful marker to distinguish lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma within a panel including antibodies against TTF-1, Napsin A, p63, SOX-2, desmocollin3, and desmoglein3.

质量


IVD

IVD

IVD

RUO

联系

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Neil A Abrahams et al.
American journal of clinical pathology, 120(3), 368-376 (2003-09-25)
We evaluated the sensitivity and specificity of cytokeratin (CK) 5/6 for distinguishing foci of atrophy from prostatic adenocarcinoma with and without previous hormonal adjuvant therapy and observed the intensity and pattern of staining in mimickers of prostatic adenocarcinoma (basal cell
Magali Lacroix-Triki et al.
Virchows Archiv : an international journal of pathology, 442(6), 548-554 (2003-04-25)
Previous studies have shown that basal-type cytokeratins (CKs) can distinguish usual ductal hyperplasia (UDH) from the spectrum of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Indeed, expression of these CKs is weak
Jorge S Reis-Filho et al.
Virchows Archiv : an international journal of pathology, 443(2), 122-132 (2003-07-29)
p63, cytokeratin (CK) 5/6 and CK 14 have been employed in diagnostic pathology as markers of basal, squamous and myoepithelial differentiation in several types of human neoplasms; however, there is scant data on the concurrent expression of these markers in
Peiguo G Chu et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 15(1), 6-10 (2002-01-18)
Cytokeratin 5/6 (CK 5/6) immunoreactivity has been observed in the vast majority of cases of malignant mesothelioma but only rarely in pulmonary adenocarcinomas. Thus, CK 5/6 has been used to distinguish malignant mesothelioma from pulmonary adenocarcinoma. However, the utility of
J E Sigel et al.
Journal of cutaneous pathology, 28(10), 520-524 (2001-12-12)
Cutaneous spindle cell squamous cell carcinoma (SSCC) is a challenging diagnosis since it may be difficult to distinguish from spindle cell melanoma, leiomyosarcoma and atypical fibroxanthoma. Furthermore, it may be difficult to demonstrate epithelial differentiation by a traditional immunohistochemical panel.

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