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453M-9

p53 (DO7) Mouse Monoclonal Antibody

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此商品	453R-1	P8999	P7874
Sigma-Aldrich 453M-9 p53 (DO7) Mouse Monoclonal Antibody	Sigma-Aldrich 453R-1 p53 (SP5) Rabbit Monoclonal Antibody	Sigma-Aldrich P8999 抗p53抗体，小鼠单克隆小鼠抗	Sigma-Aldrich P7874 Anti- p53 抗体，小鼠单克隆
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form culture supernatant	antibody form culture supernatant	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture
clone DO7, monoclonal	clone SP5, monoclonal	clone DO-7, monoclonal	clone DO-2, monoclonal
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
species reactivity human	species reactivity human	species reactivity human	species reactivity human

一般描述

Anti-p53 tumor suppressor protein recognizes a 53 kDa hosphoprotein, identified as a p53 suppressor gene product. It reacts with the mutant as well as wild form of p53. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

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p53 Positive Control Slides, Product No. 453S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

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For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

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453S

p53 Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections)

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Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2002)

Immunohistochemical expression of p53, nm23-HI, Ki67 and DNA ploidy: correlation with lymph node status and other clinical pathologic parameters in breast cancer.

C Midulla et al.

Anticancer research, 19(5B), 4033-4037 (2000-01-11)

The different clinical evolution of breast cancer with similar pathological characteristics prompted the authors to investigate the prognostic significance of different biological markers. Seventy-one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the determination of the

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

D C Quinlan et al.

Cancer research, 52(17), 4828-4831 (1992-09-01)

Mutations in the gene coding for the p53 tumor suppressor protein are common in a variety of human cancers. To assess the role of a putative mutated p53 protein in human lung cancer, a monoclonal antibody recognizing it was used

Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up.

O Caffo et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2(9), 1591-1599 (1996-09-01)

p21 protein (p21) inhibitor of cyclin-dependent kinases is a critical downstream effector in the p53-specific pathway of growth control and can also be induced by p53-independent pathways in relation to terminal differentiation. We investigated p21 immunoreactivity in 261 breast carcinomas

p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.

Z S Zeng et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 12(10), 2043-2050 (1994-10-01)

This study was performed to determine the prognostic significance of p53 gene overexpression in a homogeneous group of node-positive colorectal cancer patients. Paraffin sections from the primary tumors in 107 colorectal cancer patients who had preoperative serum carcinoembryonic antigen (CEA)

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p53 (DO7) Mouse Monoclonal Antibody

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